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Results for "

long+QT+syndrome

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

2

Peptides

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-P1604
    ATX-II
    1 Publications Verification

    		 Sodium Channel Cardiovascular Disease Inflammation/Immunology
    ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
    ATX-II
  • HY-P1604A
    ATX-II TFA
    1 Publications Verification

    		 Sodium Channel Cardiovascular Disease Inflammation/Immunology
    ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
    ATX-II TFA
  • HY-W516880
    Desmethylastemizole

    O-Demethylastemizole

    		 Drug Metabolite Parasite Histamine Receptor Potassium Channel Infection Cardiovascular Disease
    Desmethylastemizole (O-Demethylastemizole) , a metabolite of Astemizole (HY-12532), is a β-hematin (βH) inhibitor. Desmethylastemizole has an antiplasmodium activity against P. falciparum with IC50 of 0.12, 0.11 and 0.06  μM for Pf3D7, PfDd2, and PfItG strains, respectively. Desmethylastemizole is also a Histamine H1 receptor antagonist. Desmethylastemizole significantly blocks hERG K + channels and also inhibits histone-lysine N-methyltransferase EZH2 activity. Desmethylastemizole can be used for long QT syndrome and malaria research .
    Desmethylastemizole
  • HY-122024
    AZSMO-23

    		Potassium Channel Cardiovascular Disease
    AZSMO-23 is a potent hERG K + channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC50 values of 28.6, 11.2 µM, respectively. AZSMO-23 has the potential for the research of long QT syndrome .
    AZSMO-23
  • HY-145992
    KCNQ1 activator-1

    		Potassium Channel Cardiovascular Disease Neurological Disease
    KCNQ1 activator-1 (compound 5) is a potent activator of KCNQ1 channel with an EC50 of 1.69 μM. KCNQ1 activator-1 has the potential for the research of long QT syndrome (LQTS) .
    KCNQ1 activator-1

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