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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
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primary human umbilical cord vein endothelial cells

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-183448
    ETMTC

    		NF-κB Keap1-Nrf2 Caspase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Inflammation/Immunology
    ETMTC is an orally active anti-inflammatory and antioxidant agent. ETMTC inhibits IKK-mediated phosphorylation and degradation of IkBα, blocks nuclear translocation and activation of NF-κB, and reduces the expression of ICAM-1, VCAM-1, E-selectin, Th2 cytokines and eosinophil chemokines. ETMTC abrogates neutrophil adhesion to endothelial monolayers and inhibits TNF-α-induced ROS production. ETMTC activates Nrf2, and enhances the activities of mitochondrial complex I and IV. ETMTC reduces lipid peroxidation levels, oxidative DNA damage, cytochrome c and caspase 9 activity, and decreases goblet cell metaplasia and subepithelial fibrosis. ETMTC can be used for the research of inflammatory diseases and asthma .
    ETMTC

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