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Results for "

testosterone 5α-reductase

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-E70558
    5α-reductase, Rat(Sprague-Dawley) Liver

    		5 alpha Reductase Metabolic Disease
    5α-reductase, Rat (Sprague-Dawley) Liver is an enzyme involved in steroid metabolism and participates in the androgen metabolic pathway. 5α-reductase, Rat (Sprague-Dawley) Liver catalyzes the conversion of testosterone to 5α-dihydrotestosterone (DHT). DHT plays important roles in the development of male sex organs, hair growth, prostate function, and other aspects .
    5α-reductase, Rat(Sprague-Dawley) Liver
  • HY-E70558A
    5α-reductase, Rat(Sprague-Dawley) Testis

    		5 alpha Reductase Endocrinology
    5α-Reductase, Rat (Sprague-Dawley) Testis is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), which is a potent androgen involved in male sexual differentiation.5α-reductase enzyme family is comprised of 3 subfamilies and 5 isoenzyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L .
    5α-reductase, Rat(Sprague-Dawley) Testis
  • HY-165595
    Glutamic acid-alanine-glycine mixture

    		5 alpha Reductase Endocrinology
    The glutamic acid-alanine-glycine mixture is an orally active activator of testosterone 5α-reductase (5α-reductase). It promotes prostate function by enhancing the activity of 5α-reductase and increasing the levels of free amino acids. However, when combined with testosterone and estradiol (HY-B0141R), the glutamic acid-alanine-glycine mixture inhibits 5α-reductase activity and decreases the levels of free amino acids. The glutamic acid-alanine-glycine mixture can be used in research related to prostate function and endocrine disorders .
    Glutamic acid-alanine-glycine mixture
  • HY-19144
    ONO-3805

    		5 alpha Reductase Others
    ONO-3805 is an early lead compound of a non-steroidal 5α-reductase inhibitor, used to inhibit the conversion of testosterone to dihydrotestosterone, with potential effects in inhibiting benign prostatic hyperplasia.
    ONO-3805
  • HY-106129
    Izonsteride

    LY 320236

    		 5 alpha Reductase Endocrinology Cancer
    Izonsteride (Compound LY320236) is an inhibitor of 5α-reductase (IC50 = 11.6 nM for type I; 7.37 nM for type II). LY320236 inhibits the activity of steroid 5α-reductase, preventing the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 can significantly inhibit the growth of LNCaP tumors in thymic mice without exhibiting obvious host toxicity .
    Izonsteride
  • HY-106614
    Osaterone acetate

    		Androgen Receptor 5 alpha Reductase Endocrinology
    Osaterone acetate is an orally active steroid anti-androgen agent, mainly used for benign prostatic hyperplasia (BPH) in dogs. Osaterone acetate competitively antagonizes androgen receptor and inhibits 5α-reductase, reducing the concentration of dihydrotestosterone (DHT) while blocking the growth-stimulating effects of testosterone and DHT on prostate cells. Osaterone acetate can rapidly alleviate the symptoms of BPH in dogs without affecting the fertility of breeding dogs .
    Osaterone acetate
  • HY-165478
    FCE 28260

    		5 alpha Reductase Endocrinology
    FCE 28260 is an orally active 4-azacyclic 5α-reductase (5αR) inhibitor. FCE 28260 exhibits IC₅₀ values for human 5αR type 1 and 5αR type 2 of 36 and 3.3 nM, respectively, and for human and rat prostates with IC₅₀ values of 16 and 15 nM, respectively. FCE 28260 simultaneously blocks the production of dihydrotestosterone (DHT) in the prostate and peripheral tissues. FCE 28260 can significantly inhibit the induction of prostatic and seminal vesicle hyperplasia by testosterone (T) in rat models, without inhibiting the growth of the prostate in DHT implantation models. FCE 28260 can be used for the studies DHT-dependent diseases such as benign prostatic hyperplasia (BPH) .
    FCE 28260
  • HY-N20647
    Jioglutolide

    		5 alpha Reductase Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    Jioglutolide is a cyclopentane monoterpene and weak testosterone 5α-reductase inhibitor. Jioglutolide is isolated from steamed roots of Rehmannia glutinosa var. hueichingensis. Jioglutolide is applicable to research on allergies, anemia, diabetes, and menopause-related conditions .
    Jioglutolide

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