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Results for "

α-Conotoxin

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

26

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P5306
    α-Conotoxin TxID

    		nAChR Neurological Disease
    α-Conotoxin TxID is a potent α3β4 nAChR antagonist with an IC50 value of 12.5 nM. α-Conotoxin TxID has weak inhibition activity of closely related α6/α3β4 nAChR (IC50= 94 nM). α-Conotoxin TxID has the potential for novel smoking cessation drug development .
    <em>α-Conotoxin</em> TxID
  • HY-P5844
    α-Conotoxin AuIA

    		nAChR Neurological Disease
    α-Conotoxin AuIA is a potent and selective α3β4 n-nAChR inhibitor. α-Conotoxin AuIA is a α-conotoxin that can be isolated from Conus aulicus .
    <em>α-Conotoxin</em> AuIA
  • HY-P5839
    α-Conotoxin MrIC

    		nAChR Neurological Disease
    α-Conotoxin MrIC is an α7nAChR biased agonist. α-Conotoxin MrIC exclusively activates α7nAChR regulated by type II positive allosteric modulators, including PNU120596. α-Conotoxin MrIC can be used to study neurological diseases and also to probe the pharmacological properties of α7nAChR .
    <em>α-Conotoxin</em> MrIC
  • HY-P5852
    α-Conotoxin EIIB

    Alpha-Conotoxin EIIB

    		 nAChR Neurological Disease
    α-Conotoxin EIIB (Alpha-conotoxin EIIB) is a toxin peptide that can be obtained from Conus ermineus. α-Conotoxin EIIB binds to nAChR (Ki=2.2 nM). α-Conotoxin EIIB can be used in the study of neurological diseases such as schizophrenia, drug addiction, Alzheimer's disease, and Parkinson's disease .
    <em>α-Conotoxin</em> EIIB
  • HY-P5147
    α-Conotoxin GID

    		nAChR Neurological Disease
    α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR, with IC50s of 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2), respectively. α-Conotoxin GID is small disulfide-rich peptide, with potential to inhibit chronic pain. α-Conotoxin GID contains a C-terminal carboxylate, thus substitution with a C-terminal carboxamide results in loss of α4β2 nAChR. α-Conotoxin GID can be isolated from the Conus species .
    <em>α-Conotoxin</em> GID
  • HY-P1268
    α-Conotoxin PIA

    		nAChR Neurological Disease
    α-Conotoxin PIA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets nAChR subtypes containing α6 and α3 subunits. α-Conotoxin PIA has the potential for the research of Parkinson’s disease, and schizophrenia 。
    <em>α-Conotoxin</em> PIA
  • HY-P3654
    α-Conotoxin S IA

    		nAChR Neurological Disease
    α-Conotoxin SIA is a selective nicotinic acetylcholine receptor (nAChR) antagonist with high affinity for the muscle nAChR. α-Conotoxin SIA preferentially targets the α/δ interface of the muscle nAChR in mouse muscle. In contrast, for Torpedo nAChR, α-Conotoxin SIA has a much higher affinity for the α/γ than for the α/δ interface .
    <em>α-Conotoxin</em> S IA
  • HY-137788
    α-Conotoxin GI

    		nAChR Neurological Disease
    α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent .
    <em>α-Conotoxin</em> GI
  • HY-P1266
    α-Conotoxin EI

    		nAChR Neurological Disease
    α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors .
    <em>α-Conotoxin</em> EI
  • HY-P5845
    α-Conotoxin RgIA

    α-RgIA

    		 nAChR Neurological Disease
    α-Conotoxin RgIA (α-RgIA) is a specific α9α10 nAChR antagonist. α-Conotoxin RgIA can be obtained from Conus regius venom. α-Conotoxin RgIA can be used in the study of neurological diseases .
    <em>α-Conotoxin</em> RgIA
  • HY-P5146
    α-Conotoxin PeIA

    		nAChR Calcium Channel GABA Receptor Neurological Disease
    α-Conotoxin PeIA is an analgesic α-conotoxin.α-Conotoxin PeIA inhibits the α6β4, α9α10 and α3β2 nAChR.α-Conotoxin PeIA is also a potent inhibitor of N-type calcium channel via GABAB receptor activation .
    <em>α-Conotoxin</em> PeIA
  • HY-P1268A
    α-Conotoxin PIA TFA

    		nAChR Neurological Disease
    α-Conotoxin PIA TFA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets nAChR subtypes containing α6 and α3 subunits. α-Conotoxin PIA has the potential for the research of Parkinson’s disease, and schizophrenia 。
    <em>α-Conotoxin</em> PIA TFA
  • HY-P1270
    α-Conotoxin Im-I

    		nAChR Neurological Disease
    α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR .
    <em>α-Conotoxin</em> Im-I
  • HY-P5847
    α-Conotoxin GIC

    		nAChR Neurological Disease
    α-Conotoxin GIC is a potent and selective α3β2 nicotinic antagonist with an IC50 of 1.1 nM .
    <em>α-Conotoxin</em> GIC
  • HY-P5841
    α-Conotoxin LtIA

    		nAChR Neurological Disease
    α-Conotoxin LtIA is an α3β2 nAChR blocker (IC50=9.8 nM), that can be obtained from Conus litteratus venom. Alpha-Conotoxin LtIA can be used in the study of neurological diseases (such as Parkinson's disease, pain) .
    <em>α-Conotoxin</em> LtIA
  • HY-P1267
    α-Conotoxin PnIA

    		nAChR Neurological Disease
    α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer’s disease .
    <em>α-Conotoxin</em> PnIA
  • HY-P5148
    α-Conotoxin BuIA

    		nAChR Neurological Disease
    α-Conotoxin BuIA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 0.258 nM (α6/α3β2), 1.54 nM (α6/α3β4), 5.72 nM (α3β2), respectively. α-Conotoxin BuIA can be used to distinguish nAChRs containing β2- and β4-subunit, respectively. α-Conotoxin BuIA distinguishes among αxβ2 nAChRs with a rank order potency of α6>α3>α2>α4 .
    <em>α-Conotoxin</em> BuIA
  • HY-P3653
    α-Conotoxin M I

    		mAChR nAChR Neurological Disease
    α-Conotoxin M I is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs .
    <em>α-Conotoxin</em> M I
  • HY-P1267A
    α-Conotoxin PnIA TFA

    		nAChR Neurological Disease
    α-Conotoxin PnIA TFA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer’s disease .
    <em>α-Conotoxin</em> PnIA TFA
  • HY-P1269
    α-Conotoxin AuIB

    		nAChR Neurological Disease
    α-Conotoxin AuIB, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM .
    <em>α-Conotoxin</em> AuIB
  • HY-125777A
    α-Conotoxin Vc1.1 TFA

    		nAChR Neurological Disease
    α-Conotoxin Vc1.1 TFA is a disulfide-bonded peptide isolated from Conus victoriae and is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2, α3β2 and α3β4 with IC50s of 7.2 μM, 7.3 μM and 4.2 μM, respectively, and has less inhibitory effect on other nAChR subtypes. α-Conotoxin Vc1.1 TFA has the potential for neuropathic pain reserach .
    <em>α-Conotoxin</em> Vc1.1 TFA
  • HY-P1365
    α-Conotoxin MII

    α-CTxMII

    		 nAChR Neurological Disease
    α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors .
    <em>α-Conotoxin</em> MII
  • HY-P1269A
    α-Conotoxin AuIB TFA
    1 Publications Verification

    		 nAChR Neurological Disease
    α-Conotoxin AuIB TFA, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM .
    <em>α-Conotoxin</em> AuIB TFA
  • HY-P1365A
    α-Conotoxin MII TFA

    α-CTxMII TFA

    		 nAChR Neurological Disease
    α-Conotoxin MII TFA (α-CTxMII TFA), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII TFA (α-CTxMII TFA) potently blocks β3-containing neuronal nicotinic receptors .
    <em>α-Conotoxin</em> MII TFA
  • HY-P5850
    α-Conotoxin Bt1.8

    		nAChR Neurological Disease
    α-Conotoxin Bt1.8 is a potent α6/α3β2β3 and α3β2 nAChRs inhibitor with IC50s of 2.1 nM and 9.4 nM against rat α6/α3β2β3 and α3β2, respectively .
    <em>α-Conotoxin</em> Bt1.8
  • HY-P1265
    ACV1

    Vc1.1

    		 nAChR Neurological Disease
    ACV1 (Vc1.1), an α-Conotoxin, is a selective α9α10 nAChR antagonist with an IC50 of 19 nM. ACV1 is ~100-fold less potent on human α9α10 vs. rat nAChRs .
    ACV1

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