1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. SLN124

SLN124 

Cat. No.: HY-132605
Handling Instructions

SLN124 is a GalNac-siRNA targeting transmembrane serine protease 6 (Tmprss6). SLN124 is composed of a trimeric GalNAc ligand conjugated to TMPRSS6‐siRNA. SLN124 has the potential for an siRNA to restore hepcidin expression and normalise iron homeostasis in β‐thalassaemia.

For research use only. We do not sell to patients.

SLN124 Chemical Structure

SLN124 Chemical Structure

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Description

SLN124 is a GalNac-siRNA targeting transmembrane serine protease 6 (Tmprss6). SLN124 is composed of a trimeric GalNAc ligand conjugated to TMPRSS6‐siRNA. SLN124 has the potential for an siRNA to restore hepcidin expression and normalise iron homeostasis in β‐thalassaemia[1].

In Vitro

SLN124 comprises a double‐stranded 19mer RNA oligonucleotide with 2′‐O‐methyl,2′‐fluoro‐2′‐deoxy modifications and phosphorothioate bonds targeting TMPRSS6, which is linked to a tri‐antennary GalNAc unit at the 5′ end of the sense strand[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SLN124 (s.c.; 3 mg/kg; two dose on days 1 and 14), alone or in combination with the oral iron chelator deferiprone (DFP), not only suppresses Tmprss6 expression, but also normalises serum hepcidin levels, significantly improves erythropoiesis and reduced splenomegaly in 6‐month‐old female Hbbth3/+ mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SLN124
Cat. No.:
HY-132605
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