TMPRSS6
Matriptase-2; Transmembrane protease serine 6
TMPRSS6 (Matriptase-2) is a serine protease highly expressed in the liver. TMPRSS6 functions as a negative regulator of the expression of the systemic iron-regulatory hormone hepcidin.
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TMPRSS6 Related Products (7)
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Sapablursen
0 ImagesCat. No.: HY-177662CAS No.: 2273007-95-5Synonyms: IONIS-TMPRSS6-Lrx; ISIS 702843Sapablursen, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen can be used in the research of blood diseases such as pol -
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Manusiran sodium scrambled negative control
0 ImagesCat. No.: HY-147278CManusiran sodium scrambled negative control is the sequence scrambled negative control of Manusiran sodium. -
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SARSi-4 sodium scrambled negative control
0 ImagesCat. No.: HY-177663ASARSi-4 sodium scrambled negative control is the sequence scrambled negative control of SARSi-4 sodium. -
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Sapablursen sodium
0 ImagesCat. No.: HY-177662ACAS No.: 2273008-00-5Synonyms: IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodiumSapablursen sodium, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen sodium can be used in the research of blood diseas -
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Manusiran sodium
0 ImagesCat. No.: HY-147278ASynonyms: Divesiran sodium; SLN124 sodiumManusiran (SLN124) sodium, a GalNAc conjugated 19-mer siRNA targeting TMPRSS6 (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels[1][2]. -
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Manusiran
0 ImagesCat. No.: HY-147278CAS No.: 2646704-10-9Synonyms: Divesiran; SLN124Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia. -
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WGU55
0 ImagesCat. No.: HY-180217WGU55 is a selective and potent reversible type II transmembrane serine protease TMPRSS6 inhibitor with a Ki of 12.15 nM. WGU55 inhibits TMPRSS6 activity with an IC50 of 138 nMin KEK293 cells. WGU55 has a Ki of 3510 nM (SI = 289) against the homologous protease matriptase and a Ki of 5.2 μM against the coagulation key protease Factor Xa. WGU55 can be used for the research of iron overload related diseases, such as hereditary hemochromatosis. -
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