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  4. Streptavidin

Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ~0.01 pM. Streptavidin has an immunosuppressive role.
This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.

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Streptavidin

Streptavidin Chemical Structure

CAS No. : 9013-20-1

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Based on 5 publication(s) in Google Scholar

Streptavidin Related Antibodies

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Description

Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ~0.01 pM[1]. Streptavidin has an immunosuppressive role[2].
This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.

In Vitro

Streptavidin (2-200 μg/mL) significantly suppresses the proliferation of Lewis T cells to WF by 76%-83% compared with untreated responders[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Streptavidin Related Antibodies

Cell Viability Assay[1]

Cell Line: Lewis T cells
Concentration: 2-200 μg/mL
Incubation Time:
Result: Inhibited the proliferation of Lewis T cells to WF stimulators by 76%-83% compared with untreated responders, lower concentrations of 0.1 and 0.2 μg/mL did not significantly inhibit T-cell proliferation.
In Vivo

Streptavidin (8-80 mg/kg) treatment is effective in prolonging rat cardiac allografts in the high-responder WF-to-Lewis combination[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[2]
Dosage: 8, 12, 20, 40, 60, or 80 mg/kg
Administration: Administered IP for 5 consecutive days after transplantation was combined with a single dose of 0.5 mL antilymphocyte serum (ALS) on day 0
Result: Prolonged cardiac allograft survival from MST of 7.3±0.5 and 8.4±0.5 days in naive and ALS-treated controls, respectively, to 15±1, 20±3, 16±3, 17±3, and 23±2 days, respectively.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Streptavidin]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

Purity: ≥99.0%

SDS (393 KB)

COA (230 KB)

Instruction de manipulation (2659 KB)
Références
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Streptavidin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Streptavidin9013-20-1Biochemical Assay Reagentsbiotin-binding proteinversatile affinity tagvisualize biotinInhibitorinhibitorinhibit

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