2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt JAK/STAT Signaling MAPK/ERK Pathway
  3. Syk STAT ERK
  4. Syk-IN-6

Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

Syk-IN-6 Chemical Structure

Syk-IN-6 Chemical Structure

CAS No. : 3018859-95-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Syk-IN-6 Related Antibodies

Top Publications Citing Use of Products

View All STAT Isoform Specific Products:

View All Isoforms

View All ERK Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML)[1].

IC50 & Target[1]

ERK2

 

ERK1

 

STAT3

 

STAT5

 

In Vitro

Syk-IN-6 (WC36) specifically and potently suppresses oncogenic activities of Syk in AML cell lines and patient-derived AML cells[1].
Syk-IN-6 (5 μM; 16 h) inhibits FcγRI-specific antibody (IgG2)-stimulated phosphorylation of Syk, STAT3/STAT5 and ERK1/2 in naive MV4-11 cells rather not entospletinib-resistant/Syk-deficient MV4-11 cells[1].
Syk-IN-6 (0.01 μM-100 μM; 16 h) inhibits the proliferation of MV4-11 cells, HL-60 and patient-derived AML cells by SykcSH2 dose-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Syk-IN-6 Related Antibodies

Western Blot Analysis[1]

Cell Line: Raji B cell, HL-60 cell, naive and entospletinib-resistant MV4-11 cells
Concentration: 5 μM, 10 μM
Incubation Time: 16 hours
Result: Suppressed the phosphorylation and activation of Syk, ERK1/2 and STAT3/5 in entospletinib-resistant MV4-11 cells.
Was potent against phosphorylation of ERK1/2 and STAT3 in HL-60 cells.
Inhibited phosphorylation of Syk, ERK1/2 and STAT3/5 in AML cells from four patients refractory or relapsed following standard AML therapies.
Molecular Weight

390.44

Formula

C21H22N6O2
CAS No.
SMILES

O=C(C(C(NC1=NC=CC=N1)C2=CNC3=C2C=CC=C3)=[N+]=[N-])OC4CCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Syk-IN-6 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Syk-IN-63018859-95-2SykSTATERKSpleen tyrosine kinaseExtracellular signal regulated kinaseshematopoietic malignanciesacute myeloid leukemiaAMLInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Syk-IN-6
Cat. No.:
HY-151634
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.