Tetradecylphosphonic acid  (Synonyms: TDPA; Tetradecyl phosphonate)

Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors. The IC50 value for inhibition of LPA-induced calcium mobilization was 10 μM, 5.5 μM, and 3.1 μM, respectively. At a concentration of 10 μM, tetradecyl phosphonate activates a peroxisome proliferator-activated receptor γ reporter construct 4-fold when compared with the controls and partially inhibits autotaxin with an IC50 value of approximately 3 μM. Lysophosphatidic acid (LPA) , also known as autotaxin (ATX ), is a lipid signaling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase D. LPA signals through four different G protein-coupled receptors, named as LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23 . It has been reported that LPA was involved in activating peroxisome proliferator-activated receptor γ (PPARγ) .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

278.37

C₁₄H₃₁O₃P

4671-75-4

Solid

White to off-white

OP(O)(CCCCCCCCCCCCCC)=O

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)