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WS5  (Synonyms: Menthane carboxamidoethyl acetate)

Cat. No.: HY-W423502 Purity: 99.93%
COA
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WS5 (Menthane carboxamidoethyl acetate) is a cooling agent fragrance ingredient.

For research use only. We do not sell to patients.

WS5

WS5 Chemical Structure

CAS No. : 68489-14-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 g In-stock
10 g   Get quote  
50 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

WS5 Related Antibodies

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  • Purity & Documentation

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Description

WS5 (Menthane carboxamidoethyl acetate) is a cooling agent fragrance ingredient[1].

In Vitro

WS5 (Up to 5000 μg/plate) is not mutagenic in the Ames test using Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and Escherichia coli strain WP2uvrA[1].
WS5 (1008.75 μg/mL; 4-24 h) is not mutagenic to MLA cells[1].
WS5 (Up to 2000 μg/mL) is non-clastogenic in the micronucleus test using human peripheral blood lymphocytes[1].
WS5 does not react with skin peptides in the in vitro direct peptide reactivity assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WS5 Related Antibodies
In Vivo

WS5 (25-675 mg/kg; p.o.; daily; 91 days) has a no observed adverse effect level (NOAEL) for subchronic toxicity in Crl:CD(SD) rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crl:CD(SD) (male and female)[1]
Dosage: 25; 75; 225; 675 mg/kg
Administration: p.o.; daily; 91 days
Result: Showed no mortality across all doses.
Showed no treatment-related effects on body weights, food consumption, body temperature, or ophthalmic findings at any dose.
Reduced hematocrit values in males at 225 mg/kg/day, with no other treatment-related adverse effects.
Induced statistically significant increases in neutrophils, monocytes, and white blood cells in both sexes at 675 mg/kg/day.
Reduced hematocrit, hemoglobin, red blood cell counts, and mean corpuscular volume, plus increased red blood cell distribution width in both sexes at 675 mg/kg.
Increased serum creatinine, urea nitrogen, calcium, and triglyceride levels, plus total urine volume in both sexes at 675 mg/kg/day.
Decreased serum albumin/globulin ratios, chloride levels, and urine specific gravity in both sexes at 675 mg/kg.
Caused enlarged rough-surfaced kidneys in 1/10 males and pale kidneys in 1/10 females, plus increased kidney and liver weights at 675 mg/kg.
Induced kidney tubular degeneration, regeneration, dilatation, hyaline droplets, interstitial fibrosis, and tubular epithelium vacuolation in both sexes at 675 mg/kg/day.
Induced periportal hepatocellular vacuolation and centrilobular hepatocellular hypertrophy in both sexes at 675 mg/kg/day.
Induced cardiomyopathy in females at 675 mg/kg.
Showed slightly higher mean severity scores of α-2u-globulin nephropathy staining in male treatment groups, a species- and sex-specific effect not relevant to human health.
Molecular Weight

269.38

Formula

C15H27NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC(CNC([C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (371.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7122 mL 18.5611 mL 37.1223 mL
5 mM 0.7424 mL 3.7122 mL 7.4245 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.93%

SDS (398 KB)

COA (245 KB) HNMR (268 KB) LCMS (324 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7122 mL 18.5611 mL 37.1223 mL 92.8057 mL
5 mM 0.7424 mL 3.7122 mL 7.4245 mL 18.5611 mL
10 mM 0.3712 mL 1.8561 mL 3.7122 mL 9.2806 mL
15 mM 0.2475 mL 1.2374 mL 2.4748 mL 6.1870 mL
20 mM 0.1856 mL 0.9281 mL 1.8561 mL 4.6403 mL
25 mM 0.1485 mL 0.7424 mL 1.4849 mL 3.7122 mL
30 mM 0.1237 mL 0.6187 mL 1.2374 mL 3.0935 mL
40 mM 0.0928 mL 0.4640 mL 0.9281 mL 2.3201 mL
50 mM 0.0742 mL 0.3712 mL 0.7424 mL 1.8561 mL
60 mM 0.0619 mL 0.3094 mL 0.6187 mL 1.5468 mL
80 mM 0.0464 mL 0.2320 mL 0.4640 mL 1.1601 mL
100 mM 0.0371 mL 0.1856 mL 0.3712 mL 0.9281 mL
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WS5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WS568489-14-5Menthane carboxamidoethylWS 5WS-5Biochemical Assay Reagentshuman peripheral blood lymphocytesCrl:CD(SD) ratsSalmonella typhimuriumMLA cellsfreshwater algaeEscherichia coliKeratinoSens cell lineInhibitorinhibitorinhibit

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