2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. Zifaxaban

Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC50 of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research.

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Zifaxaban

Zifaxaban Chemische Struktur

CAS. Nr. : 1378266-98-8

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Zifaxaban Related Antibodies

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Beschreibung

Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC50 of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research[1].

IC50 & Target

IC50: 11.1 nM (human FXa)[1]
In Vivo

In venous thrombosis models in rats, Zifaxaban strongly suppresses thrombus formation with ED50 values of 3.09 mg/kg, and its best efficacy time occurred at 2 h after administration[1].
In arteriovenous-shunt thrombosis and carotid thrombosis models in rats, Zifaxaban inhibits thrombus formation in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

429.88

Formel

C20H16ClN3O4S
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(Cl)S1)NC[C@H]2CN(C3=CC=C(N4C=CC=CC4=O)C=C3)C(O2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation
Verweise
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Zifaxaban Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zifaxaban1378266-98-8Factor XaFxaFXa inhibitoranticoagulantorally activearterialvenous thrombosisInhibitorinhibitorinhibit

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