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  2. Bacterial
  3. 1,2-Dihydroxynaphthalene

1,2-Dihydroxynaphthalene is an intermediate isolated from the metabolism of naphthalene and has been shown to be a precursor to the formation of naphthoquinones. 1,2-Dihydroxynaphthalene can be further metabolized by some bacteria (such as Pseudomonas) to compounds such as coumarins and salicylic acid.

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1,2-Dihydroxynaphthalene

1,2-Dihydroxynaphthalene Estructura química

No. CAS : 574-00-5

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Descripciòn

1,2-Dihydroxynaphthalene is an intermediate isolated from the metabolism of naphthalene and has been shown to be a precursor to the formation of naphthoquinones. 1,2-Dihydroxynaphthalene can be further metabolized by some bacteria (such as Pseudomonas) to compounds such as coumarins and salicylic acid[1].

Cellular Effect
Cell Line Type Value Description References
HFL1 ED50
25 3
Compound: 7a
Antiproliferative activity against human fibroblast HFL1 cells
Antiproliferative activity against human fibroblast HFL1 cells
[PMID: 16539380]
HFL1 ED50
25 3
Compound: 7a
Antiproliferative activity against human fibroblast HFL1 cells
Antiproliferative activity against human fibroblast HFL1 cells
[PMID: 16539380]
T-24 ED50
13 3
Compound: 7a
Antiproliferative activity against human bladder carcinoma T24 cells
Antiproliferative activity against human bladder carcinoma T24 cells
[PMID: 16539380]
T-24 ED50
13 3
Compound: 7a
Antiproliferative activity against human bladder carcinoma T24 cells
Antiproliferative activity against human bladder carcinoma T24 cells
[PMID: 16539380]
Peso molecular

160.17

Fòrmula

C10H8O2

No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=C2C=CC=CC2=CC=C1O

Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (312.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2434 mL 31.2168 mL 62.4337 mL
5 mM 1.2487 mL 6.2434 mL 12.4867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 98.88%

Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.2434 mL 31.2168 mL 62.4337 mL 156.0842 mL
5 mM 1.2487 mL 6.2434 mL 12.4867 mL 31.2168 mL
10 mM 0.6243 mL 3.1217 mL 6.2434 mL 15.6084 mL
15 mM 0.4162 mL 2.0811 mL 4.1622 mL 10.4056 mL
20 mM 0.3122 mL 1.5608 mL 3.1217 mL 7.8042 mL
25 mM 0.2497 mL 1.2487 mL 2.4973 mL 6.2434 mL
30 mM 0.2081 mL 1.0406 mL 2.0811 mL 5.2028 mL
40 mM 0.1561 mL 0.7804 mL 1.5608 mL 3.9021 mL
50 mM 0.1249 mL 0.6243 mL 1.2487 mL 3.1217 mL
60 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.6014 mL
80 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9511 mL
100 mM 0.0624 mL 0.3122 mL 0.6243 mL 1.5608 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
1,2-Dihydroxynaphthalene
Cat. No.:
HY-128105
Cantidad:
MCE Japan Authorized Agent: