2. Anti-infection
  3. SARS-CoV
  4. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 

Cat. No.: HY-N11902 Purity: 95.51%
COA
SDS
Handling Instructions Technical Support

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent nucleocapsid (N) protein inhibitor can be isolated from Curcuma kwangsiensis. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one exhibits excellent antiviral activity against HCoV-OC43 and SARS-CoV-2,with EC50 values of 0.16 μM and 0.17 μM, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 화학구조

CAS No. : 149732-52-5

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 견적 받기
10 mg   견적 받기  
50 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 Customer Validation

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

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제품 설명

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent nucleocapsid (N) protein inhibitor can be isolated from Curcuma kwangsiensis. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one exhibits excellent antiviral activity against HCoV-OC43 and SARS-CoV-2,with EC50 values of 0.16 μM and 0.17 μM, respectively[1].

Cellular Effect
Cell Line Type Value Description References
KB IC50
5.75 3
Compound: 4
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
[PMID: 24857542]
KB IC50
5.75 3
Compound: 4
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
[PMID: 24857542]
KB IC50
5.75 3
Compound: 4
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
[PMID: 24857542]
PC-12 ED50
>50 6
Compound: 8
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
[PMID: 12350137]
PC-12 ED50
> 50 6
Compound: 8
Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
[PMID: 12350137]
PC-12 ED50
> 50 6
Compound: 8
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
[PMID: 12350137]
PC-12 ED50
> 50 6
Compound: 8
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
[PMID: 12350137]
PC-12 ED50
> 50 6
Compound: 8
Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
[PMID: 12350137]
Vero IC50
9.65 3
Compound: 4
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
[PMID: 24857542]
Vero IC50
9.65 3
Compound: 4
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
[PMID: 24857542]
Vero IC50
9.65 3
Compound: 4
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
[PMID: 24857542]
분자량

292.33

화학식

C19H16O3
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

OC(C=C1)=CC=C1/C=C/C=C/C(/C=C/C2=CC=C(C=C2)O)=O
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서
References
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1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one149732-52-5SARS-CoVSARS coronavirusAntiviral activityInhibitorinhibitorinhibit

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상품명:
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one
Cat. No.:
HY-N11902
수량:
MCE Japan Authorized Agent:

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