18-Hydroxy-11-deoxy corticosterone  (Synonyms: 18-OH-DOC; 11-Deoxy-18-hydroxycorticosterone)

18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields^[1].

346.46

C₂₁H₃₀O₄

379-68-0

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• [1]. Braley LM, et al. The effect of angiotensin II and saralasin on 18-hydroxy-11-deoxycorticosterone production by isolated human adrenal glomerulosa cells. J Clin Endocrinol Metab. 1979 Oct;49(4):600-3.  [Content Brief]

  [2]. Carroll J, et al. The relationship between plasma 18-hydroxy-11-deoxycorticosterone levels and production of hypertension in the rat. J Steroid Biochem. 1981 Oct;14(10):989-95.  [Content Brief]

  [3]. Müller J. The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: evidence for an alternative biosynthetic pathway. J Steroid Biochem. 1980 Mar;13(3):245-51.  [Content Brief]

  [4]. Slominski A, et al. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett. 1999 Jul 23;455(3):364-6.  [Content Brief]

  [5]. Giesbertz P, et al. Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes. Diabetologia. 2015 Sep;58(9):2133-43.  [Content Brief]