379-68-0
Chemical Structure
18-Hydroxy-11-deoxy corticosterone
Synonym(s): 18-OH-DOC; 11-Deoxy-18-hydroxycorticosterone
- CAS No.: 379-68-0
- Formula:C21H30O4
- Molecular Weight:346.46
IUPAC Name: (3aS,5aS,5bR,11aR,11bS,13aR)-3-hydroxy-3-(hydroxymethyl)-11a-methyl-3,3a,4,5,5a,5b,6,7,10,11,11a,11b,12,13-tetradecahydro-1H,9H-naphtho[2',1':4,5]indeno[1,7a-c]furan-9-one compound with (8R,9S,13S,14R,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one (1:1)
InChIKey: LCAOUNAHMOMSAH-OHIJVJDTSA-N
SMILES: OC[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Biological Activity: 18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields[1].
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18-Hydroxy-11-deoxy corticosterone | 18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields. | |||||||||||||||||||||
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Keywords
