18-Hydroxy-11-deoxy corticosterone
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18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields.
For research use only. We do not sell to patients.
- CAS No.: 379-68-0
- Formula: C21H30O4
- Molecular Weight:346.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 379-68-0
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Molecular Weight 346.46
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Formula C21H30O4
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SMILES
OC[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
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Synonyms
18-OH-DOC; 11-Deoxy-18-hydroxycorticosterone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Braley LM, et al. The effect of angiotensin II and saralasin on 18-hydroxy-11-deoxycorticosterone production by isolated human adrenal glomerulosa cells. J Clin Endocrinol Metab. 1979 Oct;49(4):600-3. [Content Brief]
[2]. Carroll J, et al. The relationship between plasma 18-hydroxy-11-deoxycorticosterone levels and production of hypertension in the rat. J Steroid Biochem. 1981 Oct;14(10):989-95. [Content Brief]
[3]. Müller J. The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: evidence for an alternative biosynthetic pathway. J Steroid Biochem. 1980 Mar;13(3):245-51. [Content Brief]
[4]. Slominski A, et al. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett. 1999 Jul 23;455(3):364-6. [Content Brief]
[5]. Giesbertz P, et al. Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes. Diabetologia. 2015 Sep;58(9):2133-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
18-Hydroxy-11-deoxy corticosterone Related Classifications
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