Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells

  • FEBS Lett. 1999 Jul 23;455(3):364-6. doi: 10.1016/s0014-5793(99)00889-3.
A Slominski  1 ,  C E Gomez-Sanchez ,  M F Foecking ,  J Wortsman
Affiliations
  • 1. Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA. [email protected]
PMID: 10437805 DOI: 10.1016/s0014-5793(99)00889-3
Abstract

We are now showing that cultured human melanoma cells can synthesize Steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.

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