1H-Indol-5-amine  (Synonyms: 5-Aminoindole)

1H-Indol-5-amine (5-Aminoindole) is an organic compound containing an indole ring structure and belongs to the class of indole derivatives. 1H-Indol-5-amine can serve as a key intermediate for the synthesis of other active compounds^[1][2].

1H-Indol-5-amine undergoes a three-component reaction with aromatic aldehydes and tert-butyl 2,4-dioxopiperidine-1-carboxylate under catalyst-free conditions by refluxing in ethanol, yielding 11-aryl-3H-indolo[5,4-b][1,6]naphthyridine derivatives^[1].
1H-Indol-5-amine is a ligand used for preparing AI-Sepharose hydrophobic charge induction chromatography medium, which can achieve protein adsorption and elution through hydrophobic interaction and pH-induced charge repulsion, and has application potential in protein purification^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

132.17

C₈H₈N₂

5192-03-0

Solid

Light brown to black

NC1=CC2=C(NC=C2)C=C1

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Li C, et al., Combinatorial synthesis of fused tetracyclic heterocycles containing [1,6]naphthyridine derivatives under catalyst free conditions. ACS Comb Sci. 2013 May 13;15(5):267-72.  [Content Brief]

  [2]. Zhao G, et al., 5-Aminoindole, a new ligand for hydrophobic charge induction chromatography. J Chromatogr A. 2008 Nov 21;1211(1-2):90-8.   [Content Brief]