3-Mercaptopropionic acid NHS ester

Name: 3-Mercaptopropionic acid NHS ester
Brand: MedChemExpress
SKU: HY-136159
Rating: 4.5 (1 reviews)

Cat. No.: HY-136159 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

3-Mercaptopropionic acid NHS ester 화학구조

CAS No. : 117235-10-6

사이즈	재고	수량
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE 3-Mercaptopropionic acid NHS ester

•Adv Sci (Weinh). 2025 Jan 13:e2412116. [Abstract]

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•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
순도&문서
References
고객리뷰

제품 설명

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

203.22

화학식

C₇H₉NO₄S

CAS No.

117235-10-6

Appearance

Liquid (Density: 1.40±0.1 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCS

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (492.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9208 mL	24.6039 mL	49.2078 mL
5 mM	0.9842 mL	4.9208 mL	9.8416 mL
10 mM	0.4921 mL	2.4604 mL	4.9208 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: ≥97.0%

Select Batch:

Data Sheet (273 KB) SDS (466 KB)

COA (249 KB) HNMR (267 KB) MS (78 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.9208 mL	24.6039 mL	49.2078 mL	123.0194 mL
	5 mM	0.9842 mL	4.9208 mL	9.8416 mL	24.6039 mL
	10 mM	0.4921 mL	2.4604 mL	4.9208 mL	12.3019 mL
	15 mM	0.3281 mL	1.6403 mL	3.2805 mL	8.2013 mL
	20 mM	0.2460 mL	1.2302 mL	2.4604 mL	6.1510 mL
	25 mM	0.1968 mL	0.9842 mL	1.9683 mL	4.9208 mL
	30 mM	0.1640 mL	0.8201 mL	1.6403 mL	4.1006 mL
	40 mM	0.1230 mL	0.6151 mL	1.2302 mL	3.0755 mL
	50 mM	0.0984 mL	0.4921 mL	0.9842 mL	2.4604 mL
	60 mM	0.0820 mL	0.4101 mL	0.8201 mL	2.0503 mL
	80 mM	0.0615 mL	0.3075 mL	0.6151 mL	1.5377 mL
	100 mM	0.0492 mL	0.2460 mL	0.4921 mL	1.2302 mL