5-Bromo-3-phenyl salicylic acid

Art. -Nr.: HY-118819 Reinheit: 98.00%: Data Sheet
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5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with K_i of 140 nM.

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5-Bromo-3-phenyl salicylic acid Chemische Struktur

CAS. Nr. : 99514-99-5

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Beschreibung	5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with K_i of 140 nM^[1].
IC₅₀ & Target	K_i: 140 nM (AKR1C1), 1.97 μM (AKR1C2), 21 μM (AKR1C3)
In Vitro	5-Bromo-3-phenyl salicylic acid (10 μM) inhibits metabolism of progesterone in cell BAECs^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 5-Bromo-3-phenyl salicylic acid Related Antibodies
Molekulargewicht	293.11
Formel	C₁₃H₉BrO₃
CAS. Nr.	99514-99-5
Appearance	Solid
Color	Off-white to light yellow
SMILES	O=C(C1=CC(Br)=CC(C2=CC=CC=C2)=C1O)O
Versand	Room temperature in continental US; may vary elsewhere.
Speicherung	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reinheit & Dokumentation	Purity: 98.00% Select Batch: Data Sheet (269 KB) SDS (393 KB) COA (250 KB) Handling Instructions (2659 KB)
Verweise	[1]. El-Kabbani O, et al., Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64. [Content Brief]

5-Bromo-3-phenyl salicylic acid Related Classifications

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Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Bromo-3-phenyl salicylic acid99514-99-5Aldose Reductasepremenstrual syndromerodent tumorhuman tumorInhibitorinhibitorinhibit

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5-Bromo-3-phenyl salicylic acid

5-Bromo-3-phenyl salicylic acid Related Antibodies

Spezialitätsempfehlungen

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5-Bromo-3-phenyl salicylic acid Related Antibodies

5-Bromo-3-phenyl salicylic acid Related Classifications

Molaritätsrechner

Verdünnungsrechner