1. GPCR/G Protein
  2. Cannabinoid Receptor

APD 371 

Cat. No.: HY-111110
Handling Instructions

APD 371 is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist, with an EC50 of 6.2 nM for hCB2.

For research use only. We do not sell to patients.

APD 371 Chemical Structure

APD 371 Chemical Structure

CAS No. : 1268881-20-4

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

APD 371 is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist, with an EC50 of 6.2 nM for hCB2.

IC50 & Target

EC50: 6.2 nM (hCB2)[1].

In Vitro

A comprehensive in vitro profile of APD 371 (6) shows that single digit nanomolar potency and full intrinsic efficacy are maintained in all species assessed, and that APD 371 is highly selective for CB2 over CB1 in both binding and functional assays. Furthermore, APD 371 induces efficient receptor internalization (~106% relative to the CB1/2 agonist CP55,940) in CHO cells expressing HA-tagged rat CB2 suggesting that, according to the hypothesis, APD 371 would be able to drive agonist-induced receptor recycling[1].

In Vivo

APD 371 significantly increases paw withdrawal thresholds at doses ≥3 mg/kg PO (ED50=2.3 mg/kg). In a separate experiment, a single dose of APD 371 (10 mg/kg, PO) inhibits paw withdrawal threshold for up to 4 hours after administration. Seperately, the analgesic effects of APD 371 are shown to be highly likely mediated via activity at CB2 receptors[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7979 mL 13.9895 mL 27.9791 mL
5 mM 0.5596 mL 2.7979 mL 5.5958 mL
10 mM 0.2798 mL 1.3990 mL 2.7979 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

357.41

Formula

C₁₈H₂₃N₅O₃

CAS No.

1268881-20-4

SMILES

O=C(C1=NN(C(N=CC=2)=CN2=O)C3=C1C[[email protected]@]4([H])[[email protected]]3([H])C4)N[[email protected]](CO)C(C)(C)C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
APD 371
Cat. No.:
HY-111110
Quantity:

APD 371

Cat. No.: HY-111110