CAY 10465
Based on 1 publication(s) in Google Scholar
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.75%
- CAS. Nr.: 688348-33-6
- Formel: C15H9Cl2F3
- Molecular Weight:317.13
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CAY 10465
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Biologische Aktivität
Ki: 0.2 nM (AhR)[1]
CAY 10465 (Compound 4i) is a selective and high-affinity AhR receptor agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM)[1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 688348-33-6
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Appearance Solid
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Molecular Weight 317.13
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Formel C15H9Cl2F3
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Color White to off-white
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SMILES
FC(C1=CC=C(/C=C/C2=CC(Cl)=CC(Cl)=C2)C=C1)(F)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Identification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion. [Abstract]2026 Jan 15;33(1):91-101.e12. PMID: 41483807
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (315.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. [Content Brief]
[2]. Naem E, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1533 mL | 15.7664 mL | 31.5328 mL | 78.8320 mL |
| 5 mM | 0.6307 mL | 3.1533 mL | 6.3066 mL | 15.7664 mL | |
| 10 mM | 0.3153 mL | 1.5766 mL | 3.1533 mL | 7.8832 mL | |
| 15 mM | 0.2102 mL | 1.0511 mL | 2.1022 mL | 5.2555 mL | |
| 20 mM | 0.1577 mL | 0.7883 mL | 1.5766 mL | 3.9416 mL | |
| 25 mM | 0.1261 mL | 0.6307 mL | 1.2613 mL | 3.1533 mL | |
| 30 mM | 0.1051 mL | 0.5255 mL | 1.0511 mL | 2.6277 mL | |
| 40 mM | 0.0788 mL | 0.3942 mL | 0.7883 mL | 1.9708 mL | |
| 50 mM | 0.0631 mL | 0.3153 mL | 0.6307 mL | 1.5766 mL | |
| 60 mM | 0.0526 mL | 0.2628 mL | 0.5255 mL | 1.3139 mL | |
| 80 mM | 0.0394 mL | 0.1971 mL | 0.3942 mL | 0.9854 mL | |
| 100 mM | 0.0315 mL | 0.1577 mL | 0.3153 mL | 0.7883 mL |
CAY 10465 Related Classifications
HY-112627 Related Classifications
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