2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. CAY 10465

CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).

For research use only. We do not sell to patients.

CAY 10465 Chemical Structure

CAY 10465 Chemical Structure

CAS No. : 688348-33-6

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 97 In-stock
Solid
5 mg USD 88 In-stock
10 mg USD 154 In-stock
50 mg USD 594 In-stock
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Based on 1 publication(s) in Google Scholar

CAY 10465 Related Antibodies

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Description

CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).

IC50 & Target

Ki: 0.2 nM (AhR)[1]
In Vitro

CAY 10465 (Compound 4i) is a selective and high-affinity AhR receptor agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM)[1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAY 10465 Related Antibodies
Molecular Weight

317.13

Formula

C15H9Cl2F3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=CC=C(/C=C/C2=CC(Cl)=CC(Cl)=C2)C=C1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (315.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1533 mL 15.7664 mL 31.5328 mL
5 mM 0.6307 mL 3.1533 mL 6.3066 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1533 mL 15.7664 mL 31.5328 mL 78.8320 mL
5 mM 0.6307 mL 3.1533 mL 6.3066 mL 15.7664 mL
10 mM 0.3153 mL 1.5766 mL 3.1533 mL 7.8832 mL
15 mM 0.2102 mL 1.0511 mL 2.1022 mL 5.2555 mL
20 mM 0.1577 mL 0.7883 mL 1.5766 mL 3.9416 mL
25 mM 0.1261 mL 0.6307 mL 1.2613 mL 3.1533 mL
30 mM 0.1051 mL 0.5255 mL 1.0511 mL 2.6277 mL
40 mM 0.0788 mL 0.3942 mL 0.7883 mL 1.9708 mL
50 mM 0.0631 mL 0.3153 mL 0.6307 mL 1.5766 mL
60 mM 0.0526 mL 0.2628 mL 0.5255 mL 1.3139 mL
80 mM 0.0394 mL 0.1971 mL 0.3942 mL 0.9854 mL
100 mM 0.0315 mL 0.1577 mL 0.3153 mL 0.7883 mL
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CAY 10465 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY 10465688348-33-6CAY10465CAY-10465Aryl Hydrocarbon ReceptorAhRInhibitorinhibitorinhibit

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