1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. G-744

G-744 

Cat. No.: HY-102036
Handling Instructions

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis.

For research use only. We do not sell to patients.

G-744 Chemical Structure

G-744 Chemical Structure

CAS No. : 1346669-54-2

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Description

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1].

IC50 & Target

IC50: 2 nM (Btk), 64 nM (CD86)[1].

In Vivo

G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) protects Lewis rats from collagen-induced arthritis dose-dependently[1].

Animal Model: Female Lewis rat based CIA models[1].
Dosage: 6.25, 12.25, 25 mg/kg.
Administration: Orally, b.i.d., daily for 17 days.
Result: All three doses resulted in a significant dose-dependent inhibition of ankle thickness between day 10 and day 17 (onset of increase in ankle diameter on day 9).
Molecular Weight

527.64

Formula

C₂₉H₂₉N₅O₃S

CAS No.

1346669-54-2

SMILES

CN(C1=O)C=C(C2=CC=CC(N3C(C(SC4=C5CC(C)(C)C4)=C5CC3)=O)=C2CO)C=C1NC6=CC=NC=N6

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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