1346669-54-2
1346669-54-2
Chemical Structure
G-744
- CAS No.: 1346669-54-2
- Formula:C29H29N5O3S
- Molecular Weight:527.64
IUPAC Name: 2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-6,6-dimethyl-3,4,6,7-tetrahydro-2H-cyclopenta[4,5]thieno[2,3-c]pyridin-1(5H)-one
InChIKey: QAESSIFTPVEYRY-UHFFFAOYSA-N
SMILES: CN(C1=O)C=C(C2=CC=CC(N3C(C(SC4=C5CC(C)(C)C4)=C5CC3)=O)=C2CO)C=C1NC6=CC=NC=N6
Biological Activity: G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1].
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G-744 | G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis. | |||||||||||||||||||||
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References
Keywords
