2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. G-744

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis.

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G-744

G-744 Chemical Structure

CAS No. : 1346669-54-2

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G-744 Related Antibodies

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Description

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1].

IC50 & Target

IC50: 2 nM (Btk), 64 nM (CD86)[1].
In Vivo

G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) protects Lewis rats from collagen-induced arthritis dose-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rat based CIA models[1].
Dosage: 6.25, 12.25, 25 mg/kg.
Administration: Orally, b.i.d., daily for 17 days.
Result: All three doses resulted in a significant dose-dependent inhibition of ankle thickness between day 10 and day 17 (onset of increase in ankle diameter on day 9).
Masse moléculaire

527.64

Formule

C29H29N5O3S
CAS No.
SMILES

CN(C1=O)C=C(C2=CC=CC(N3C(C(SC4=C5CC(C)(C)C4)=C5CC3)=O)=C2CO)C=C1NC6=CC=NC=N6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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G-744 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G-7441346669-54-2G744G 744BtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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