2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. HCGRP-(8-37)

HCGRP-(8-37)  (Synonyms: Human α-CGRP (8-37))

製品番号: HY-P1014 純度: 99.51%
COA 取扱説明書 Technical Support

HCGRP-(8-37) (Human α-CGRP (8-37)) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of the CGRP receptor, with an IC50 of 32.1 pM against the CGRP receptor. HCGRP-(8-37) blocks adenylate cyclase activation induced by CGRP receptor ligands and attenuates vascular responses triggered by CGRP. HCGRP-(8-37) reduces capsaicin-induced vasodilation in porcine nasal mucosa and superficial skin. HCGRP-(8-37) serves as a research tool to distinguish effects mediated by CGRP or calcitonin receptors, and to investigate CGRP-induced vascular effects.

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HCGRP-(8-37)

HCGRP-(8-37) 構造式

CAS 番号 : 119911-68-1

容量 価格（税別） 在庫状況 数量
500 μg $180 在庫あり
1 mg $290 在庫あり
5 mg $725 在庫あり
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Based on 2 publication(s) in Google Scholar

HCGRP-(8-37) 関連抗体

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製品説明

HCGRP-(8-37) (Human α-CGRP (8-37)) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of the CGRP receptor, with an IC50 of 32.1 pM against the CGRP receptor. HCGRP-(8-37) blocks adenylate cyclase activation induced by CGRP receptor ligands and attenuates vascular responses triggered by CGRP. HCGRP-(8-37) reduces capsaicin-induced vasodilation in porcine nasal mucosa and superficial skin. HCGRP-(8-37) serves as a research tool to distinguish effects mediated by CGRP or calcitonin receptors, and to investigate CGRP-induced vascular effects[1][2].

IC50 & Target

CGRP receptor[1]
体外実験

HCGRP-(8-37) (10 min at 37°C) acts as a CGRP receptor antagonist in rat liver plasma membranes. It inhibits CGRP- and calcitonin-induced adenylate cyclase activation in a dose-dependent manner, but does not affect basal, epinephrine- or glucagon-stimulated activities[1].
HCGRP-(8-37) (60 min at 37°C) binds to calcitonin receptors in LLC-PK1 porcine kidney cells in a dose-dependent manner[1].
HCGRP-(8-37) (15 min at 37°C) acts as a calcitonin receptor agonist in LLC-PK1 porcine kidney cells, which dose-dependently stimulates cAMP production without antagonizing calcitonin- or CGRP-induced cAMP production[1].
HCGRP-(8-37) potently inhibits CGRP-mediated adenylate cyclase activation in cell-free rat liver plasma membrane preparations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HCGRP-(8-37) 関連抗体
体内実験

HCGRP-(8-37) (16 µM; local intra-arterial infusion; 20 minutes) significantly attenuates both CGRP- and capsaicin-mediated vasodilation in the pig nasal mucosa and reduces the integrated and duration-based capsaicin- and CGRP-mediated skin vasodilation responses, confirming it acts as a functional CGRP receptor antagonist in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Domestic pigs (either sex, 17-22 kg)[2]
Dosage: 16 µM
Administration: local intra-arterial infusion; 20 minutes
Result: Significantly attenuated capsaicin-evoked increases in nasal vascular conductance and decreases in nasal cavity volume.
Significantly reduced capsaicin-evoked superficial skin blood flow when calculated as area under the curve (AUC); capsaicin-induced skin peak blood flow remained unchanged (96% of control, not significant), but the duration of the skin response was significantly reduced to 69% of control .
Significantly reduced CGRP-evoked increases in nasal vascular conductance and decreases in nasal cavity volume.
Significantly attenuated CGRP-evoked superficial skin blood flow, with reductions seen in AUC, peak response, and response duration.
分子量

3125.59

分子式

C139H230N44O38
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe
Sequence Shortening

VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : ≥ 20 mg/mL (6.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3199 mL 1.5997 mL 3.1994 mL
5 mM 0.0640 mL 0.3199 mL 0.6399 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 20 mg/mL (6.40 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3199 mL 1.5997 mL 3.1994 mL 7.9985 mL
5 mM 0.0640 mL 0.3199 mL 0.6399 mL 1.5997 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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HCGRP-(8-37) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCGRP-(8-37)119911-68-1Human α-CGRP (8-37)CGRP ReceptorCalcitonin gene-related peptide receptorCGRP receptorantagonistvasodilation
Inhibitorinhibitorinhibit

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