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HY-14644

" in MedChemExpress (MCE) Product Catalog:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-14644
    Apilimod
    35+ Cited Publications

    STA 5326; LAM-002A free base; AIT-101

    		 Interleukin Related PIKfyve Inflammation/Immunology Cancer
    Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.
    Apilimod
  • HY-14644A
    Apilimod mesylate
    35+ Cited Publications

    STA 5326 mesylate; LAM-002A; AIT-101 mesylate

    		 Interleukin Related PIKfyve Inflammation/Immunology Cancer
    Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.
    Apilimod mesylate
  • HY-14644B
    Apilimod hydrochloride

    STA 5326 HYdrochloride; LAM-002A free base HYdrochloride; AIT-101 HYdrochloride

    		 NOD-like Receptor (NLR) Infection Inflammation/Immunology
    Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.
    Apilimod hydrochloride

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