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Apilimod

(Synonyms: STA 5326; LAM-002A free base; AIT-101)
44 Cited Publications
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Based on 44 publication(s) in Google Scholar

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. Apilimod is a potent and highly selective PIKfyve inhibitor.

For research use only. We do not sell to patients.

  • Purity: 99.80%
  • CAS No.: 541550-19-0
  • Formula: C23H26N6O2
  • Molecular Weight:418.49
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Apilimod Chemical Structure
    Apilimod Chemical Structure
  • Experimental Validation Results for Apilimod
  • Experimental Validation Results for Apilimod
  • Experimental Validation Results for Apilimod
  • Experimental Validation Results for Apilimod
  • Experimental Validation Results for Apilimod
CAS No.: 541550-19-0
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Apilimod Chemical Structure
    Apilimod Chemical Structure
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    Apilimod purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 28;16(1):4945. [Abstract]

    Customer Validation
     M-CSF-stimulated macropinocytosis induces phosphorylation of the WNK1 kinase region in bone marrow myeloid progenitors. Mouse myeloid progenitors were isolated from the bone marrow and stimulated with M-CSF in the presence of vehicle, WNK463, or indicated macropinocytosis inhibitors EIPA, Apilimod (10 μM), and LY294002. Cells were harvested after 1 h, then assayed for WNK1 phosphorylation.

  • 1/16

    Apilimod purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Mar 27;11(1):1620. [Abstract]

    Customer Validation
     Inhibition of entry of SARS-CoV, MERS-CoV, and MHV S pseudovirions by a PIKfyve inhibitor apilimod. HeLa/mCEACAM, 293/hACE2, HeLa/hDPP4 cells were pretreated with different concentrations of Apilimod (0-1 μM; 1 h) and transduced with MHV S, SARS-CoV S, MERS-CoV S pseudovirions, respectively. The luciferase activity was measured 40 h post transduction. VSV-G pseudovirions were used as a control.

  • 1/16

    Apilimod purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Mar 27;11(1):1620. [Abstract]

    Customer Validation
     Inhibition of MHV A59 infection by apilimod. The 17Cl.1 cells were pretreated with 3, 10, 30, 100, 300 nM apilimod for 30 min and infected by MHV A59 at MOI = 0.01. Viral infection and cell viability were determined by using qPCR and MTT assay, respectively.

  • 1/16

    Apilimod purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Mar 27;11(1):1620. [Abstract]

    Customer Validation
     HEK 293/hACE2 cells were pretreated with apimod (1–300 nM; 1 h) and then inoculated with SARS-CoV-2 S protein pseudovirus in the presence of the drug. Luciferase activity was measured 40 hours after transfection.

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    Apilimod purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2016 Dec;73(24):4717-4737. [Abstract]

    Customer Validation
     PIKfyve inhibition affects the autophagy pathway. Cellular LC3-II levels are measured by Western blot after cells are treated with or without concanamycin A (50 nM) during the last 4 h of the preincubation step with Apilimod(0.5 μM; 21 h).

  • Apilimod