1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP

Niraparib R-enantiomer (Synonyms: MK 4827 (R-enantiomer))

Cat. No.: HY-10619D Purity: 98.58% ee.: 99.94%
Handling Instructions

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM.

For research use only. We do not sell to patients.

Niraparib R-enantiomer Chemical Structure

Niraparib R-enantiomer Chemical Structure

CAS No. : 1038915-58-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 242 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 990 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Niraparib R-enantiomer:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM.

IC50 & Target[1]

PARP-1

2.4 nM (IC50)

In Vitro

Niraparib R-enantiomer (MK-4827 R-enantiomer) resolution of Niraparib R-enantiomer give compounds Niraparib R-enantiomer and Niraparib S-enantiomer, both showing excellent inhibition of PARP-1. Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). Given this improved potency and similar in vitro turnover in human liver microsomes (HLM Clint, Niraparib R-enantiomer=4, Niraparib S-enantiomer=3 μL/min/mgP), Niraparib S-enantiomer (Niraparib) is focused on[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (99.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1212 mL 15.6060 mL 31.2120 mL
5 mM 0.6242 mL 3.1212 mL 6.2424 mL
10 mM 0.3121 mL 1.5606 mL 3.1212 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

320.39

Formula

C₁₉H₂₀N₄O

CAS No.

1038915-58-0

SMILES

O=C(C1=CC=CC2=CN(C3=CC=C([[email protected]@H]4CNCCC4)C=C3)N=C12)N

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Niraparib R-enantiomer
Cat. No.:
HY-10619D
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Niraparib R-enantiomer

Cat. No.: HY-10619D