1. GPCR/G Protein
  2. TSH Receptor
  3. ML-109

ML-109 

Cat. No.: HY-114116 Purity: 99.12%
Handling Instructions

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

For research use only. We do not sell to patients.

ML-109 Chemical Structure

ML-109 Chemical Structure

CAS No. : 1186649-91-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 403 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

IC50 & Target

EC50: 40 nM (TSHR)[1].

In Vitro

ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)[1].

Molecular Weight

523.58

Formula

C₃₁H₂₉N₃O₅

CAS No.

1186649-91-1

SMILES

CC(NC1=CC=C(OCC2=CC(C(N3CC4=CC=CC=C4)NC5=C(C(O)=CC=C5)C3=O)=CC=C2OC)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (159.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9099 mL 9.5496 mL 19.0993 mL
5 mM 0.3820 mL 1.9099 mL 3.8199 mL
10 mM 0.1910 mL 0.9550 mL 1.9099 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.12%

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Keywords:

ML-109ML109ML 109TSH ReceptorThyrotropin receptorThyroid-stimulating hormone ReceptorInhibitorinhibitorinhibit

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ML-109
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HY-114116
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