1. GPCR/G Protein
  2. TSH Receptor

ML-109 

Cat. No.: HY-114116
Handling Instructions

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

For research use only. We do not sell to patients.

ML-109 Chemical Structure

ML-109 Chemical Structure

CAS No. : 1186649-91-1

Size Price Stock
5 mg USD 550 Get quote
10 mg USD 850 Get quote
25 mg USD 1750 Get quote

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Description

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

IC50 & Target

EC50: 40 nM (TSHR)[1].

In Vitro

ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9099 mL 9.5496 mL 19.0993 mL
5 mM 0.3820 mL 1.9099 mL 3.8199 mL
10 mM 0.1910 mL 0.9550 mL 1.9099 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

523.58

Formula

C₃₁H₂₉N₃O₅

CAS No.

1186649-91-1

SMILES

CC(NC1=CC=C(OCC2=CC(C(N3CC4=CC=CC=C4)NC5=C(C(O)=CC=C5)C3=O)=CC=C2OC)C=C1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ML-109
Cat. No.:
HY-114116
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ML-109

Cat. No.: HY-114116