2. 天然物
  3. Plants
  4. Cucurbitaceae
  5. Hemsleya chinensis Cogn. ex Forbes et Hemsl.

Hemsleya chinensis Cogn. ex Forbes et Hemsl.

Hemsleya chinensis Cogn. ex Forbes et Hemsl. (7):

製品番号 製品名 CAS 番号 純度 構造式
  • HY-N1988
    Cucurbitacin IIa

    Cucurbitacin IIa

    		58546-34-2 99.90%
    Cucurbitacin IIa (Hemslecin A) is an orally active, blood-brain barrier-permeable EGFR inhibitor with an IC50 of 1.455 nM against human EGFR. Cucurbitacin IIa induces caspase-3-dependent apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton via actin aggregation, arrests the cell cycle at the G2/M phase, and exerts anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway. Cucurbitacin IIa can be used in the research of inflammation-related diseases, depression, and cancers such as non-small cell lung cancer.
    Cucurbitacin IIa
  • HY-N17988
    Hemslonin A 72348-82-4
    Hemslonin A is a triterpenoid found in the tubers of Hemsleya chinensis.
    Hemslonin A
  • HY-N17987
    Hemsloside G1 129385-80-4
    Hemsloside G1 is a saponin that found in the rhizome of Hemsleya graciliflora.
    Hemsloside G1
  • HY-N17983
    Hemsloside H1 102146-27-0
    Hemsloside H1 is an oleanolic acid-type bisdesmosidic saponin that can be isolated from the rhizomes of Hemsleya chinensis.
    Hemsloside H1
  • HY-N17984
    Hemsloside Ma3 96158-11-1
    Hemsloside Ma3 is an anionic surfactant and solubilizer. Hemsloside Ma3 is an oleanolic acid bisdesmosidic saponin that can be isolated from the rhizomes of Hemsleya macrosperma and Hemsleya chinensis. Hemsloside Ma3 improves the water solubility of saikosaponin a, a poorly water-soluble monodesmosidic saponin, and its solubilizing effect appears near the critical micelle concentration. At a constant ionic strength, Hemsloside Ma3 exhibits the property of reduced surface tension with the increase in hydrogen ion concentration.
    Hemsloside Ma3
  • HY-N1988R
    Cucurbitacin IIa (Standard) 58546-34-2
    Cucurbitacin IIa (Hemslecin A) (Standard) is the analytical standard for Cucurbitacin IIa (HY-N1988). This product is used for research and analytical applications. Cucurbitacin IIa is an orally active, blood-brain barrier-penetrating EGFR inhibitor with an IC50 of 1.455 nM for human EGFR. Cucurbitacin IIa induces caspase-3 dependent cell apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton through actin aggregation, blocks the cell cycle at the G2/M phase, and inhibits the EGFR-MAPK signaling pathway to exert anti-inflammatory activity. Cucurbitacin IIa can be used in research on inflammatory-related diseases, depression, and non-small cell lung cancer and other cancers.
    Cucurbitacin IIa (Standard)
  • HY-N12552
    Cucurbitacin IIa 2-O-β-D-glucoside 77704-34-8
    Cucurbitacin IIa 2-O-β-D-glucoside is a glycoside cucurbitacin isolated from the genus Hemsleya (Cucurbitaceae). Extracts of Hemsleya have the potential to be used in research on bronchitis, bacillary dysentery, and tuberculosis.
    Cucurbitacin IIa 2-O-β-D-glucoside