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Pirinixil (Synonyms: BR-931)

Cat. No.: HY-100334
Handling Instructions

Pirinixil is a hypolipidemic agent of low toxicity.

For research use only. We do not sell to patients.

Pirinixil Chemical Structure

Pirinixil Chemical Structure

CAS No. : 65089-17-0

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Description

Pirinixil is a hypolipidemic agent of low toxicity.

In Vivo

Pirinixil is a hypolipidemic agent of low toxicity. Total cholesterol is reduced by Pirinixi in the spleen, kidney and heart of rats. Pirinixil decreases the estimated total body cholesterol approximately 40%[1]. Pirinixil increases plasma cholesterol levels significantly without affecting plasma triglycerides. Liver cholesterol and triglycerides are markedly reduced by Pirinixil, while combined plasma and liver lipid levels decrease approximately 20%. Liver HMG-CoA reductase activity is not affected, but cholesterol 7α-hydroxylase is significantly reduced by Pirinixil[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Male Sprague-Dawley rats, weighing 220 to 230 g at the start of each experiment, are used in all studies. They are kept in an air-conditioned environment, with controlled lighting and free access to water. Dietary treatments are (A) standard diet for rats and (B) 2% cholesterol+2% cholic acid regimen. Both diets are administered ad libitum, respectively for 1 and 2 weeks (standard diet) and for 2 weeks (cholesterolcholic acid diet). Groups of 5 rats in each of the 3 experiments (1 and 2 weeks with the standard diet, 2 weeks with the cholesterol-cholic acid diet) are administered Pirinixil daily in carboxymethylcellulose vehicle by gastric intubation, at the doses of 20 mg/kg. Controls are given a similar volume of vehicle daily by intubation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

366.87

Formula

C₁₆H₁₉ClN₄O₂S

CAS No.

65089-17-0

SMILES

O=C(NCCO)CSC1=NC(NC2=CC=CC(C)=C2C)=CC(Cl)=N1

Shipping

Room temperature in continental US; may vary elsewhere

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Pirinixil
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Pirinixil

Cat. No.: HY-100334