2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Selegiline hydrochloride

セレギリン塩酸塩  (Synonyms: Selegiline (hydrochloride); Deprenyl (hydrochloride); (-)-Selegiline (hydrochloride); (-)-Deprenyl (hydrochloride))

製品番号: HY-14199 純度: 99.94%
COA 取扱説明書 Technical Support

Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 14611-52-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
100 mg $60 在庫あり
250 mg $120 在庫あり
500 mg   お問い合わせ  
1 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Other Forms of Selegiline hydrochloride:

セレギリン塩酸塩 関連抗体

Top Publications Citing Use of Products

    Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250.  [Abstract]

    Schematic of the experimental timeline for analyzing the effects of the MAO-B inhibitor Selegiline hydrochloride (10 mg/kg, ip, 7 days) on CFA-induced allodynia and NETs formation.

    Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250.  [Abstract]

    Representative blots and quantification of MPO and citH3 in the spinal cords of vehicle, Selegiline hydrochloride, selegiline + CI-amidine, and Selegiline hydrochloride (10 mg/kg, ip, 7 days) + PMA groups.

    Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250.  [Abstract]

    Double immunofluorescence staining for citH3 (red) and MPO (green) in the spinal cords. NETs visualized by colocalization of citH3 and MPO staining (merged images; n = 3, scale bars: 50 or 100 μm). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the vehicle group mice. #P < 0.05, compared with the Selegiline hydrochloride (10 mg/kg, ip, 7 days) group mice.

    Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250.  [Abstract]

    ELISAs detecting IL-1β, IL-6, and TNF-α in the spinal cords (n = 5, IL-1β: F3, 16 = 35.98, P < 0.0001; IL-6: F3, 16 = 58.79, P < 0.0001; TNF-α: F3, 16 = 155.5, P < 0.0001). The expression levels in the vehicle group were set to 1 for quantification. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the vehicle group mice. #P < 0.05, compared with the Selegiline hydrochloride (10 mg/kg, ip, 7 days) group mice.

    Selegiline hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250.  [Abstract]

    Representative blots and quantification of GPR35 in the spinal cords of vehicle, FMD, FMD +  Selegiline hydrochloride (10 mg/kg, ip, 7 days), and FMD + 5-HIAA + PMA groups (n = 5, F3, 16 = 23.56, P < 0.0001).

    Monoamine Oxidase アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    MAO-A MAO-B

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder[1][2][3].

    IC50 & Target[1]

    MAO-B

    51 nM (IC50)

    体外実験

    Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner[1].
    Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    セレギリン塩酸塩 関連抗体
    体内実験

    Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6J mice (20-22 g)[4]
    Dosage: 1 mg/kg
    Administration: I.p. daily for 24 days
    Result: Single injection did not acutely affect mouse locomotor activity.
    14 consecutive days administration did not affect food reward.
    Reduced Cocaine self-administration, and reduced DOPAC and 5-HIAA concentrations in frontal cortex.
    分子量

    223.74

    分子式

    C13H18ClN
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CN(CC#C)[C@H](C)CC1=CC=CC=C1.Cl
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (446.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 33.33 mg/mL (148.97 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.4695 mL 22.3474 mL 44.6947 mL
    5 mM 0.8939 mL 4.4695 mL 8.9389 mL
    10 mM 0.4469 mL 2.2347 mL 4.4695 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL (22.35 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 5 mg/mL (22.35 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.96%

    COA (250 KB) HNMR (260 KB) RP-HPLC (255 KB) MS (70 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 4.4695 mL 22.3474 mL 44.6947 mL 111.7368 mL
    5 mM 0.8939 mL 4.4695 mL 8.9389 mL 22.3474 mL
    10 mM 0.4469 mL 2.2347 mL 4.4695 mL 11.1737 mL
    15 mM 0.2980 mL 1.4898 mL 2.9796 mL 7.4491 mL
    20 mM 0.2235 mL 1.1174 mL 2.2347 mL 5.5868 mL
    25 mM 0.1788 mL 0.8939 mL 1.7878 mL 4.4695 mL
    30 mM 0.1490 mL 0.7449 mL 1.4898 mL 3.7246 mL
    40 mM 0.1117 mL 0.5587 mL 1.1174 mL 2.7934 mL
    50 mM 0.0894 mL 0.4469 mL 0.8939 mL 2.2347 mL
    60 mM 0.0745 mL 0.3725 mL 0.7449 mL 1.8623 mL
    80 mM 0.0559 mL 0.2793 mL 0.5587 mL 1.3967 mL
    100 mM 0.0447 mL 0.2235 mL 0.4469 mL 1.1174 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Selegiline hydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Selegiline14611-52-0Deprenyl(-)-Selegiline(-)-DeprenylMonoamine OxidaseMAOMAO-BParkinson'sAlzheimer'sdepressiveInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

    		  

    カスタマ需要量 *

    お名前 *

    		 

    タイトル

    メールアドレス *

    		 

    電話番号 *

    デパートメント

    		 

    組纖名 *

    市区町村

    都道府県

    国或いは地域 *

    		      

    必ず会社名を記載ください。個人への返信は行いません。

    備考

    バルクお問い合わせ

    Inquiry Information

    製品名:
    Selegiline hydrochloride
    製品番号:
    HY-14199
    数量:
    MCE 日本正規代理店:

    カスタマーレビュー

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    製品名

    		  

    Lot #

    お名前 *

    		 

    メールアドレス *

    電話番号 *

    		 

    部門 *

    組纖名 *

    		 

    国或いは地域 *

    備考

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.