2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15746S
    (rac)-Dobutamine-d4 hydrochloride 1246815-74-6 98%
    (rac)-Dobutamine-d4 (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
    (rac)-Dobutamine-d4 hydrochloride
  • HY-15853A
    MK-7246 S enantiomer 2310135-53-4 98%
    MK-7246 S enantiomer is the less active enantiomer of MK-7246. MK-7246 is a potent and selective CRTH2 antagonist.
    MK-7246 S enantiomer
  • HY-15895R
    Aprocitentan (Standard) 1103522-45-7 98%
    Aprocitentan (Standard) is the analytical standard of Aprocitentan. This product is intended for research and analytical applications. Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.
    Aprocitentan (Standard)
  • HY-159686
    Aclidinium 727649-81-2 98%
    Aclidinium is a long-acting muscarinic antagonist and long-acting β2-adrenoceptor (β2-AR) agonist with bronchodilator activity. Aclidinium can reduce hyperinflation of the lungs and increase lung function and exercise endurance time. Aclidinium is used in research on chronic obstructive pulmonary disease (COPD).
    Aclidinium
  • HY-15971R
    AMD 3465 hexahydrobromide (Standard) 185991-07-5
    AMD 3465 (hexahydrobromide) (Standard) is the analytical standard of AMD 3465 (hexahydrobromide). This product is intended for research and analytical applications. AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
    AMD 3465 hexahydrobromide (Standard)
  • HY-159802
    Tolamolol 38103-61-6 98%
    Tolamolol is a selective beta-adrenergic antagonist with significant activity in reducing exercise-induced ST-segment depression. Tolamolol is clinically equivalent to propranolol in suppressing angina and exhibits greater cardiac selectivity. Tolamolol is effective in reducing the frequency of angina attacks and the amount of glyceryl trinitrate used. Tolamolol is effective in lowering blood pressure and has a positive effect on increasing the amount of exercise that can be performed before angina attacks. The use of Tolamolol also helps improve the suppression of arrhythmias.
    Tolamolol
  • HY-159825
    Branosotine 2412849-26-2 98%
    Branosotine (compound 1-1) is a potent agonist of somatostatin receptor (SSTR2), with the EC50 of ＜0.1 nM.
    Branosotine
  • HY-160416
    THR-β modulator-2 2542029-56-9 98%
    THR-β modulator-2 (compound 40) is a thyroid hormone receptor β (THR-β) modulator.
    THR-β modulator-2
  • HY-160485
    G-4'G-7S 1630724-68-3 98%
    G-4'G-7S is a endogenous metabolite of genistein (HY-14596). G-4'G-7S can be used for the research of estrogenic activity.
    G-4'G-7S
  • HY-160932
    RS-15385-198 121961-55-5 98%
    RS-15385-198 is the enantiomer of Delequamine (RS-15385-197) (HY-106874). RS-15385-198 exhibits a pKi of 6.32 for α2-adrenoceptors in the rat cortex. RS-15385-198 is an antagonist for UK-14304 (HY-B0659) in the rat vas deferens and in the guinea-pig ileum.
    RS-15385-198
  • HY-160984
    Rotraxate 92071-51-7 98%
    Rotraxate (TEI 5103) is an orally active anti-ulcer compound. Rotraxate can increase blood flow to the gastric mucosa and promote the integrity of the gastric mucosa. Rotraxate can be used to study the protective effects of drugs on the gastric mucosa, especially in investigating how drugs can prevent or treat gastric ulcers by acting directly on the gastric mucosa.
    Rotraxate
  • HY-16289R
    Lodoxamide tromethamine (Standard) 63610-09-3 98%
    Lodoxamide (tromethamine) (Standard) is the analytical standard of Lodoxamide (tromethamine). This product is intended for research and analytical applications. Lodoxamide tromethamine (U-42585E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.
    Lodoxamide tromethamine (Standard)
  • HY-163373
    13,14-Dihydro-15-keto prostaglandin D1 1392219-79-2 98%
    13,14-Dihydro-15-keto prostaglandin D1 is a derivative of prostaglandin D1.
    13,14-Dihydro-15-keto prostaglandin D1
  • HY-16346R
    Netupitant (Standard) 290297-26-6
    Netupitant (Standard) is the analytical standard of Netupitant. This product is intended for research and analytical applications. Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect.
    Netupitant (Standard)
  • HY-163712
    17-Epiestriol 1228-72-4 98%
    17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase.
    17-Epiestriol
  • HY-164032
    Dimethandrolone undecanoate 366472-45-9 98%
    Dimethandrolone undecanoate (7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate) exhibits withrogens and progesterone activity. Dimethandrolone undecanoate inhibits production of gonadotropins, suppresses testosterone production, and thus inhibits sperm production. Dimethandrolone undecanoate is potent for development of male hormone contraceptives.
    Dimethandrolone undecanoate
  • HY-16474R
    Relugolix (Standard) 737789-87-6 98%
    Relugolix (Standard) is the analytical standard of Relugolix. This product is intended for research and analytical applications. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209). Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al.
    Relugolix (Standard)
  • HY-16504R
    Treprostinil sodium (Standard) 289480-64-4 98%
    Treprostinil (sodium) (Standard) is the analytical standard of Treprostinil (sodium). This product is intended for research and analytical applications. Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil sodium (Standard)
  • HY-16504S
    Treprostinil-13C2-d1 Sodium 98%
    Treprostinil-13C2-d1 (Sodium) (UT-15-13C2-d1(sodium)) is deuterium and 13C labeled Treprostinil (sodium). Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil-13C2-d1 Sodium
  • HY-16508R
    Ulipristal acetate (Standard) 126784-99-4 98%
    Ulipristal acetate (Standard) is the analytical standard of Ulipristal acetate. This product is intended for research and analytical applications. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.
    Ulipristal acetate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity