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Cat. No.: HY-15853A

MK-7246 S enantiomer

MK-7246 S enantiomer is the less active enantiomer of MK-7246. MK-7246 is a potent and selective CRTH2 antagonist.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAS No.: 2310135-53-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

MK-7246 S enantiomer is the less active enantiomer of MK-7246. MK-7246 is a potent and selective CRTH2 antagonist.

All Prostaglandin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	864 nM Compound: 3	Antagonist activity at human recombinant CRTH2 receptor expressed in HEK293 cells assessed as inhibition of DK-PGD2-induced intracellular cAMP formation Antagonist activity at human recombinant CRTH2 receptor expressed in HEK293 cells assessed as inhibition of DK-PGD2-induced intracellular cAMP formation	[PMID: 21106375]

In Vitro

The affinity and selectivity of the MK-7246 are superior to the MK-7246 S enantiomer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No. 2310135-53-4
Molecular Weight 416.47
Formula C₂₁H₂₁FN₂O₄S
SMILES

CN([C@H]1CCC2=C(C3=CC=CC=C3N2C1)CC(O)=O)S(=O)(C4=CC=C(C=C4)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.