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Cat. No.: HY-15971R

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AMD 3465 hexahydrobromide (Standard)

(Synonyms: GENZ-644494 hexahydrobromide (Standard))

AMD 3465 (hexahydrobromide) (Standard) is the analytical standard of AMD 3465 (hexahydrobromide). This product is intended for research and analytical applications. AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

For research use only. We do not sell to patients.

CAS No.: 185991-07-5
Formula: C₂₄H₄₄Br₆N₆
Molecular Weight:896.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AMD 3465 hexahydrobromide (Standard) Chemical Structure

CAS No.: 185991-07-5

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 185991-07-5
Molecular Weight 896.07
Formula C₂₄H₄₄Br₆N₆
SMILES

[H]Br.[H]Br.[H]Br.[H]Br.[H]Br.[H]Br.C1(CNCC2=CC=C(CN3CCNCCCNCCNCCC3)C=C2)=NC=CC=C1
Synonyms

GENZ-644494 hexahydrobromide (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70(5):752-61. [Content Brief]

[2]. Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67(2):651-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AMD 3465 hexahydrobromide (Standard)

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AMD 3465 hexahydrobromide (Standard)

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Chemical Information

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References

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Help & FAQs

AMD 3465 hexahydrobromide (Standard) Related Classifications

HY-15971R Related Classifications