2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00423
    CRTH2-IN-1 926661-54-3 98%
    CRTH2-IN-1 (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC50 of 6 nM in a human DP2 binding assay.
    CRTH2-IN-1
  • HY-Y1217R
    1-Cyclohexanol (Standard) 108-93-0 98%
    1-Cyclohexanol (Hydroxycyclohexane; NSC 54711) (Standard) is the analytical standard of 1-Cyclohexanol (HY-Y1217). This product is intended for research and analytical applications. 1-Cyclohexanol is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly.
    1-Cyclohexanol (Standard)
  • HY-Y1819R
    2-Acetonaphthone (Standard) 93-08-3 98%
    2-Acetonaphthone is a synthetic fragrance material. 2-Acetonaphthone increases ROS under UVA/sunlight, leading to endoplasmic reticulum stress and decreased mitochondrial membrane potential. 2-Acetonaphthone can be used as an adulterant in a variety of cosmetics. 2-Acetonaphthone can be used for the study of skin keratinization
    2-Acetonaphthone (Standard)
  • HY-100007R
    Vonoprazan (Standard) 881681-00-1 98%
    Vonoprazan (Standard) is the analytical standard of Vonoprazan. This product is intended for research and analytical applications. Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori.
    Vonoprazan (Standard)
  • HY-100037R
    NT157 (Standard) 1384426-12-3 98%
    NT157 (Standard) is the analytical standard of NT157 (HY-100037). This product is intended for research and analytical applications. NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway.
    NT157 (Standard)
  • HY-10011BR
    (Rac)-SCH 563705 (Standard) 2701435-64-3 98%
    (Rac)-SCH 563705 (Standard) is the analytical standard of (Rac)-SCH 563705 (HY-10011B). This product is intended for research and analytical applications. (Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values ​​of 1.3 nM and 7.3 nM and Ki values ​​of 1 nM and 3 nM, respectively.
    (Rac)-SCH 563705 (Standard)
  • HY-100183R
    GSK2239633A (Standard) 1240516-71-5 98%
    GSK2239633A (Standard) is the analytical standard of GSK2239633A (HY-100183). This product is intended for research and analytical applications. GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96.
    GSK2239633A (Standard)
  • HY-100238R
    Antihistamine-1 (Standard) 1186430-60-3 98%
    Antihistamine-1 (Standard) is the analytical standard of Antihistamine-1 (HY-100238). This product is intended for research and analytical applications. Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
    Antihistamine-1 (Standard)
  • HY-100271R
    Org41841 (Standard) 301847-37-0 98%
    Org41841 (Standard) is the analytical standard of Org41841 (HY-100271). This product is intended for research and analytical applications. Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.
    Org41841 (Standard)
  • HY-100300R
    AGN 192836 (Standard) 171102-29-7 98%
    AGN 192836 (Standard) is the analytical standard of AGN 192836 (HY-100300). This product is intended for research and analytical applications. AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
    AGN 192836 (Standard)
  • HY-100339R
    GSK583 (Standard) 1346547-00-9 98%
    GSK583 (Standard) is the analytical standard of GSK583 (HY-100339). This product is intended for research and analytical applications. GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.
    GSK583 (Standard)
  • HY-100441R
    Treprostinil (Standard) 81846-19-7 98%
    Treprostinil (Standard) is the analytical standard of Treprostinil. This product is intended for research and analytical applications. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil (Standard)
  • HY-100449A
    (S)-AL-8810 1224444-55-6 98%
    (S)-AL 8810 is an 11β-fluoro analog of PGF2α that acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the inverse, (S), or "natural" configuration at C-15 relative to AL 8810, which is 15-(R).
    (S)-AL-8810
  • HY-100452R
    TCS-OX2-29 (Standard) 372523-75-6 98%
    TCS-OX2-29 (Standard) is the analytical standard of TCS-OX2-29 (HY-100452). This product is intended for research and analytical applications. TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1.
    TCS-OX2-29 (Standard)
  • HY-100550R
    MSDC 0160 (Standard) 146062-49-9 98%
    MSDC 0160 (Standard) is the analytical standard of MSDC 0160 (HY-100550). This product is intended for research and analytical applications. MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease.
    MSDC 0160 (Standard)
  • HY-100559R
    SecinH3 (Standard) 853625-60-2 98%
    SecinH3 (Standard) is the analytical standard of SecinH3 (HY-100559). This product is intended for research and analytical applications. SecinH3 is an antagonist of cytohesins with IC50s of 5.4 μM, 2.4 μM, 5.4 μM, 5.6 μM, 5.6 μM and 65 μM for hCyh1, hCyh2, mCyh3, hCyh3, drosophila steppke and yGea2-S7, respectively.
    SecinH3 (Standard)
  • HY-100573R
    Necrosulfonamide (Standard) 1360614-48-7 98%
    Necrosulfonamide (Standard) is the analytical standard of Necrosulfonamide (HY-100573). This product is intended for research and analytical applications. Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.
    Necrosulfonamide (Standard)
  • HY-100661R
    Cetirizine Impurity D (Standard) 346451-15-8
    Cetirizine Impurity D (Standard) is the analytical standard of Cetirizine Impurity D. This product is intended for research and analytical applications. Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
    Cetirizine Impurity D (Standard)
  • HY-100717R
    HT-2157 (Standard) 303149-14-6 98%
    HT-2157 (Standard) is the analytical standard of HT-2157 (HY-100717). This product is intended for research and analytical applications. HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
    HT-2157 (Standard)
  • HY-100850R
    Piperoxan hydrochloride (Standard) 135-87-5 98%
    Piperoxan (hydrochloride) (Standard) is the analytical standard of Piperoxan (hydrochloride) (HY-100850). This product is intended for research and analytical applications. Piperoxan (Benodaine) hydrochloride is an α2 adrenoceptor antagonist. Piperoxan hydrochloride is the first-generation antihistamine.
    Piperoxan hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity