2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-169069
    Antifungal agent 110 98%
    Antifungal agent 110 exhibits fungicidal activity toward Botrytis cinerea and Rhizoctonia solani. Antifungal agent 110 displays antifungal activity against R. solani with an EC50 value of 0.27 mg/L. Antifungal agent 110 is promising for research of plant diseases.
    Antifungal agent 110
  • HY-169079
    RNAP-NusG-IN-1 98%
    RNAP-NusG-IN-1 is an RNAP-NusG inhibitor. RNAP-NusG-IN-1 has antibacterial activity against Gram-positive bacteria, with the strongest activity against Streptococcus pneumoniae, showing an MIC value of 1 μg/mL.
    RNAP-NusG-IN-1
  • HY-169099
    Antiproliferative agent-56 98%
    Antiproliferative agent-56 (Compound 31) is an antimalarial agent, that inhibits Plasmodium falciparum 3D7 (Pf3D7) with an IC50 >12.5 (48h) and 0.03 μM (98h), and reveals a slow-acting property.
    Antiproliferative agent-56
  • HY-169104
    InhA-IN-8 98%
    InhA-IN-8 (compound 6c) is an orally active inhibitor of Mycobacterium tuberculosis InhA (enoyl ACP reductase). InhA-IN-8 has good inhibitory activity against Mtb UalRv (MIC = 0.5-1 μg/mL). InhA-IN-8 can be used in research on acute tuberculosis model mice.
    InhA-IN-8
  • HY-169105
    DNA Gyrase-IN-12 98%
    DNA Gyrase-IN-12 (Compound 6d) is a DNA gyrase inhibitor. DNA Gyrase-IN-12 has Antibacterial activity and MIC value of vancomycin-intermediate S. aureus (VISA) and Enterococcus faecalis strains is between 0.031 and 0.0625 μg/mL.
    DNA Gyrase-IN-12
  • HY-169108
    DprE1-IN-11 98%
    DprE1-IN-11 (compound 3) is an orally active DprE1 inhibitor with antituberculosis activity against MTB H37Rv and MDR-MTB strains (MIC <0.029-0.095 μM).
    DprE1-IN-11
  • HY-169112
    HCV-IN-46 98%
    HCV-IN-46 (compound 6d) is a HCV inhibitor with an EC50 value of 3.717 μM. HCV-IN-46 has antiviral activity.
    HCV-IN-46
  • HY-16911R
    AFN-1252 (Standard) 620175-39-5
    Apramycin (Standard) is the analytical standard of Apramycin. This product is intended for research and analytical applications. 0
    AFN-1252 (Standard)
  • HY-169154
    ChlaDUB1-IN-1 98%
    ChlaDUB1-IN-1 (Compound 8) is an inhibitor for Chlamydia deubiquitinase 1 (ChlaDUB1). ChlaDUB1-IN-1 can be used in antimicrobial research.
    ChlaDUB1-IN-1
  • HY-169160
    Anti-MRSA agent 18 98%
    Anti-MRSA agent 18 (E17) is an inhibitor of MRSA with MIC values of 2 μg/mL for S. aureus and 4 μg/mL for MRSA, respectively. Anti-MRSA agent 18 interacts with bacterial cell membrane phosphatidylglycerol and cardiolipin, causing changes in cell membrane permeability and polarization, increased intracellular ROS, and DNA and protein leakage, thereby accelerating bacterial death.
    Anti-MRSA agent 18
  • HY-169161
    Antibacterial agent 245 2757692-28-5 98%
    Antibacterial agent 245 (Dc-2) is an antibacterial against plant pathogen fungi and bacteria with an EC50 value of 1.29 μg/mL for Botrytis cinerea.
    Antibacterial agent 245
  • HY-169165
    14α-Demethylase-IN-1 3026164-55-3 98%
    14α-Demethylase-IN-1 (compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent. 14α-Demethylase-IN-1 (48 h) exhibits MIC50 values of 2.47 μM, 1.23 μM, 19.70 μM, and 19.70 μM for C. albicans, C. parapsilosis, C. krusei, and C. glabrata, respectively.
    14α-Demethylase-IN-1
  • HY-169166
    HIV-1 protease-IN-14 98%
    HIV-1 protease-IN-14 (compound 5ae) is a potent HIV-1 protease inhibitor with Ki values of 0.28, 56.9 nM for WT HIV-1 PR, R41T HIV-1 PR, respectively. HIV-1 protease-IN-14 shows low cytotoxicity.
    HIV-1 protease-IN-14
  • HY-169175
    CN-CC-861 98%
    CN-CC-861 is a broad-spectrum antibiotic. CN-CC-861 shows antibiotic activities for susceptible and multidrug-resistant bacteria. CN-CC-861 shows potent bactericidal activity in vivo.
    CN-CC-861
  • HY-169176
    LpxC-IN-15 98%
    LpxC-IN-15 ((S)-13j) is a potent LpxC inhibitor with Ki values of 9.05, 5.6 nM for EcLpxC C63A, PaLpxC, respectively. LpxC-IN-15 shows antibacterial activity.
    LpxC-IN-15
  • HY-169191
    Quorum sensing-IN-8 98%
    Quorum sensing-IN-8 (compound 5e) has anti-biofilm activity. Quorum sensing-IN-8 can be used for the study of antimicrobial resistance.
    Quorum sensing-IN-8
  • HY-169202
    Antifungal agent 118 3055029-65-4 98%
    Antifungal agent 118 (compund C22) inhibits the hyphal growth of V. mali by inducing oxidative damage and disrupting the integrity of the cell membrane.
    Antifungal agent 118
  • HY-169224
    SARS-CoV-2-IN-100 374543-46-1 98%
    SARS-CoV-2-IN-100 (Compound 172) is an inhibitor of SARS-CoV-2, demonstrating broad-spectrum antiviral activity against various SARS-CoV-2 variants. SARS-CoV-2-IN-100 exhibits synergistic effects with Nirmatrelvir, which can reduce the risk of antiviral drug resistance.
    SARS-CoV-2-IN-100
  • HY-169252
    Antifungal agent 121 343362-45-8 98%
    Antifungal agent 121 (compound TM11) is a fungicide. The chemical nature of Antifungal agent 121 is a benzimidazole-acrylonitrile derivative.
    Antifungal agent 121
  • HY-169256
    ZINC4497834 767310-01-0 98%
    ZINC4497834 is an inhibitor of SARS-CoV-2 major protease Mpro. ZINC4497834 can be used in anti-COVID19 research.
    ZINC4497834
Cat. No. Product Name / Synonyms Application Reactivity