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Cat. No.: HY-169176

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LpxC-IN-15

LpxC-IN-15 ((S)-13j) is a potent LpxC inhibitor with K_i values of 9.05, 5.6 nM for EcLpxC C63A, PaLpxC, respectively. LpxC-IN-15 shows antibacterial activity.

For research use only. We do not sell to patients.

Formula: C₃₂H₃₂N₄O₅
Molecular Weight:552.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

LpxC-IN-15 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

LpxC-IN-15 ((S)-13j) is a potent LpxC inhibitor with K_i values of 9.05, 5.6 nM for EcLpxC C63A, PaLpxC, respectively. LpxC-IN-15 shows antibacterial activity^[1].

IC₅₀ & Target

K_i: 9.05 nM (EcLpxC C63A); 5.6 nM (PaLpxC)^[1]

Chemical Information

Molecular Weight 552.62
Formula C₃₂H₃₂N₄O₅
SMILES

O=C(NO)[C@@H](OCC1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3)CNC(C4=CC(C=CN5)=C5C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mielniczuk S, et al. Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity. J Med Chem. 2024 Oct 10;67(19):17363-17391. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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