2. Infection

Infection (感染症)

Infection

関連製品

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

製品番号 製品名 CAS 番号 純度 構造式
  • HY-176531
    Antiviral agent 69 3049804-05-6 98%
    Antiviral agent 69 (Compound L2) is a capsid protein residue THR155-targeting inhibitor of phytoviral intercellular traffic. Antiviral agent 69 has an excellent antiviral activity against Potato virus Y (PVY) with an EC50 of 128.10 μg/mL for inactivation effect. Antiviral agent 69 effectively decreases viral accumulation in host plant Nicotiana benthamiana, promising for novel pesticide research and development.
    Antiviral agent 69
  • HY-176552
    Tubulin polymerization-IN-83
    Tubulin polymerization-IN-83 (Compound A23) is a flavonol derivative. Tubulin polymerization-IN-83 exhibits antifungal activity against various phytopathogenic fungi, with an EC50 of 0.338 μg/mL against Botrytis cinerea. Tubulin polymerization-IN-83 exerts its effects by targeting β-tubulin, disrupting mycelial morphology, and increasing cell membrane permeability, with relatively low ecological and environmental risks.
    Tubulin polymerization-IN-83
  • HY-176748
    Primidophos 39247-96-6
    Primidophos is an ingredient in insecticide and acaricide compositions. Primidophos can be used in research on the prevention and control of insect and acarid pests.
    Primidophos
  • HY-176750
    HMRZ-62 287118-33-6
    HMRZ-62 is an antibacterial agent. HMRZ-62 exhibits antibacterial activity against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) and Vancomycin (HY-B0671)-resistant Enterococcus faecalis (VRE).
    HMRZ-62
  • HY-176776
    Antibacterial agent 287 2131216-13-0
    Antibacterial agent 287 (Compound 26), a derivative of Deoxynybomycin (HY-116926), is an antibacterial agent. Antibacterial agent 287 has potent antibacterial activity against a variety of Gram-negative bacterium with MICs of 0.5, 0.5 and 0.06 μg/mL for WT S. aureus, WT E. coli and E. coli ΔtolC, respectively. Antibacterial agent 287 can be used for multidrug-resistant (MDR) bacterium infections research.
    Antibacterial agent 287
  • HY-177012
    ADP-Hep 322640-23-3
    ADP-Hep (ADP-heptose) is a precursor for lipopolysaccharide assembly in Gram-negative bacteria. ADP-Hep is used in studies of Escherichia coli infection.
    ADP-Hep
  • HY-177020
    GS-6620 PM 1191237-49-6
    GS-6620 PM (Compound 2) is an analog of 2′-C-methyl 4-aza-7,9-dideaza adenosine. 2′-C-methyl 4-aza-7,9-dideaza adenosine is an inhibitor of HCV replication in cell culture. GS-6620 PM can be used in the study of hepatitis C virus (HCV) infection.
    GS-6620 PM
  • HY-177071
    Asuptegravir 2765212-92-6
    Asuptegravir (Compound 1) is an inhibitor of HIV integrase activity. Asuptegravir inhibits HIV in HEK293T cells (EC50 = 1.08 nM). Asuptegravir can be studied in anti-AIDs/HIV research.
    Asuptegravir
  • HY-177097
    Lenacapavir pacfosacil 2937414-47-4
    Lenacapavir pacfosacil (Example 44) is a viral capsid and nucleocapsid inhibitor. Lenacapavir pacfosacil has antiviral effects. Lenacapavir pacfosacil can be used for research of Retroviridae infection, including an HIV infection.
    Lenacapavir pacfosacil
  • HY-177300
    TLR7/8 agonist 13 1402802-45-2 98%
    TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 μM) and TLR8 (LEC [hTLR8] = 1.6 μM). TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 μM). TLR7/8 agonist 13 induces endogenous IFNα, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus.
    TLR7/8 agonist 13
  • HY-177301
    PDF-IN-2 949197-97-1
    PDF-IN-2 is a peptidyl deformylase (PDF) inhibitor. PDF-IN-2 has average IC50 values of 0.25, 0.50 and 0.34 nM, and average MIC values of 0.16, 0.33 and 0.25 μg/mL for Streptococcus pneumoniae PDF WT, G70V and G70D, respectively. PDF-IN-2 can be used in the research of infectious diseases.
    PDF-IN-2
  • HY-177322
    sCNH240 1357746-77-0 98%
    sCNH240 (Compound P1) is an oral active and selective Rv1625c/Cya activator. sCNH240 has significant anti-tuberculosis activity with a MIC90 of 1.24 μM for Mycobacterium tuberculosis (Mtb) H37Rv strain on cholesterol. sCNH240 can be used for tuberculosis research.
    sCNH240
  • HY-177325
    MmpL3-IN-5 1432641-65-0 98%
    MmpL3-IN-5 (Compound 3G) is a MmpL3 inhibitor. MmpL3-IN-5 has an antitubercular activity with a pMIC of 7.0  μM for Mycobacterium tuberculosis H37Rv strain. MmpL3-IN-5 can be used for tuberculosis research.
    MmpL3-IN-5
  • HY-177332
    SLC-391 1783825-18-2 98%
    SLC-391 is an orally active AXL kinase inhibitor with an IC50 of 9.6 nM against AXL kinase. SLC-391 inhibits Gas6-induced AXL-dependent phosphorylation of Akt. SLC-391 inhibits SARS-CoV-2 infection, entry and replication in cells. SLC-391 suppresses cancer cell proliferation. SLC-391 inhibits tumor growth in mouse solid tumor xenograft models. SLC-391 can be used for the research of COVID-19, influenza virus infection, triple-negative breast cancer, chronic myeloid leukemia and non-small cell lung cancer.
    SLC-391
  • HY-177337
    N-Didesmethyladitoprim 56066-19-4
    N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743). Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics.
    N-Didesmethyladitoprim
  • HY-177378
    HBV-IN-53 2243162-67-4 98%
    HBV-IN-53 (Compound 1) is an HBV inhibitor. HBV-IN-53 reduces the level of HBV DNA in serum. The inhibitory activity of HBV-IN-53 in combination with Tenofovir disoproxil fumarate (HY-13782) exhibits an additive effect on HBV inhibition.
    HBV-IN-53
  • HY-177441
    Apicidin C 366448-28-4
    Apicidin C (Compound 5a) is a cyclic tetrapeptide. Apicidin C has an antiprotozoal and antimalarial activity against Eimeria tenella (IC50: 6 nM) by reversibly inhibiting HDAC acyivity. Apicidin C can be used for malaria infections research.
    Apicidin C
  • HY-177532
    Apo-Enopeptin methyl ester 98%
    Apo-Enopeptin methyl ester is a derivative of Enopeptin A (HY-P1708). Apo-Enopeptin methyl ester is promising for research of Gram-positive and Gram-negative bacteria.
    Apo-Enopeptin methyl ester
  • HY-177539
    ent-Epanorin 3061155-25-4 98%
    ent-Epanorin is an enantiomer of Epanorin (HY-N16418). ent-Epanorin has more potent antibacterial and antiparasitic activity against Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923) and Giardiaduodenalis 713 compared to Epanorin.
    ent-Epanorin
  • HY-177557
    IDO-IN-19 2033173-20-3 98%
    IDO-IN-19 (Compound I) is a free base of an imidazole-isoindole derivative. IDO-IN-19 can inhibit the activity of Indoleamine 2,3-Dioxygenase (IDO). IDO-IN-19 can block the decomposition of tryptophan and restore the function of T cells. IDO-IN-19 can be used for the researches of cancer, immunology, infection and neurological disease, such as breast cancer and Alzheimer's disease.
    IDO-IN-19
製品番号 製品名 / Synonyms Application Reactivity