N-Didesmethyladitoprim
N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743). Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics.
For research use only. We do not sell to patients.
- CAS No.: 56066-19-4
- Formula: C13H17N5O2
- Molecular Weight:275.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 56066-19-4
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Molecular Weight 275.31
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Formula C13H17N5O2
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SMILES
NC1=NC=C(CC2=CC(OC)=C(C(OC)=C2)N)C(N)=N1
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Synonyms
N-Didesmethyl-ADP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang L, et al. Metabolism and Disposition of Aditoprim in Swine, Broilers, Carp and Rats. Sci Rep. 2016 Feb 3;6:20370. [Content Brief]
[2]. Then RL, et al. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 1988 Feb;35(2):114-20. [Content Brief]
[3]. Cheng G, et al. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017 Feb 1;7:41370. [Content Brief]
[4]. Wang X, et al. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 2015 Dec;35(12):1531-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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