56066-19-4
56066-19-4
Chemical Structure
N-Didesmethyladitoprim
Synonym(s): N-Didesmethyl-ADP
- CAS No.: 56066-19-4
- Formula:C13H17N5O2
- Molecular Weight:275.31
SMILES: NC1=NC=C(CC2=CC(OC)=C(C(OC)=C2)N)C(N)=N1
Biological Activity: N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743). Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics[1][2][3][4].
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N-Didesmethyladitoprim | N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743). Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics. | |||||||||||||||||||||
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References
- [1]. Wang L, et al. Metabolism and Disposition of Aditoprim in Swine, Broilers, Carp and Rats. Sci Rep. 2016 Feb 3;6:20370. [Content Brief]
- [2]. Then RL, et al. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 1988 Feb;35(2):114-20. [Content Brief]
- [3]. Cheng G, et al. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017 Feb 1;7:41370. [Content Brief]
- [4]. Wang X, et al. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 2015 Dec;35(12):1531-8. [Content Brief]
Keywords
