1. Cell Cycle/DNA Damage
    Anti-infection
  2. Antifolate
    Bacterial
  3. Aditoprime

Aditoprime (Synonyms: Aditoprim)

Cat. No.: HY-139743
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Aditoprime (Aditoprim), a selective bacterial dihydrofolate reductase (DHFR) inhibitor, inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime inhibits E.coli and L.casei DHFR with IC50 of 47 and 520 nM, respectively. Aditoprime has a broad antimicrobial spectrum, good antibacterial activity and excellent pharmacokinetics.

For research use only. We do not sell to patients.

Aditoprime Chemical Structure

Aditoprime Chemical Structure

CAS No. : 56066-63-8

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Description

Aditoprime (Aditoprim), a selective bacterial dihydrofolate reductase (DHFR) inhibitor, inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime inhibits E.coli and L.casei DHFR with IC50 of 47 and 520 nM, respectively. Aditoprime has a broad antimicrobial spectrum, good antibacterial activity and excellent pharmacokinetics[1][2][3].

In Vitro

Aditoprime has the same antibacterial spectrum as TMP. Salmonellaand Streptococcus from swine, E. coli and Salmonella from chickens, E. coli, Streptococcus, Mannheimia, and Pasteurella from calves, Streptococcus and Mannheimia from sheep, and E. coli, Flavobacterium columnare, A. baumannii and Y. ruckeri from fishes are highly susceptible to Aditoprime (MIC or MIC50 ≤ 4 μg/mL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aditoprime (Aditoprim) has longer elimination half-lives (3.3~14.8 h) and higher distribution volumes (4.6~10.4 L/kg) than those of Trimethoprim (TMP) in pig, calf, monkey, sheep and some other animal species, and a similar pattern is observed for Aditoprime where the distribution volume is about four times higher than that of TMP[1].
Aditoprime (10 -40 mg/kg; b.w.; intramuscularly) shows efficacy in infected swine (swine streptococcosis)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

303.36

Formula

C15H21N5O2

CAS No.
SMILES

NC1=NC=C(CC2=CC(OC)=C(N(C)C)C(OC)=C2)C(N)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Aditoprime
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