56066-63-8
Chemical Structure
Aditoprime
Synonym(s): Aditoprim
- CAS No.: 56066-63-8
- Formula:C15H21N5O2
- Molecular Weight:303.36
IUPAC Name: 5-(4-(dimethylamino)-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine
InChIKey: QBQMXWZTRRWPGK-UHFFFAOYSA-N
SMILES: NC1=NC=C(CC2=CC(OC)=C(N(C)C)C(OC)=C2)C(N)=N1
Biological Activity: Aditoprime (Aditoprim) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics[1][2][3].
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Aditoprime | 99.68% | Aditoprime (Aditoprim) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics. | ||||||||||||||||||||
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Aditoprime (Standard) | ≥98% | Aditoprime (Standard) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics. | ||||||||||||||||||||
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- [1]. Then RL, et al. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 1988;35(2):114-120. [Content Brief]
- [2]. Cheng G, et al. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017;7:41370. Published 2017 Feb 1. [Content Brief]
- [3]. Wang X, et al. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 2015;35(12):1531-1538. [Content Brief]
Keywords
