2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-180399
    Antibacterial agent 323 25303-05-3
    Antibacterial agent 323 is an antifbacterial agent with weak activity. Antibacterial agent 323 can be used for the research of bacterial nfection, such as Acinetobacter baumannii strains.
    Antibacterial agent 323
  • HY-180407
    UGM-IN-1 1027102-50-6
    UGM-IN-1 (compound 107) is a selective competitive inhibitor of Mycobacterium tuberculosis UDP-Galp mutase (UGM), encoded by Rv3809c. UGM-IN-1 inhibits the conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf), thereby blocking the synthesis of key components of the mycobacterial cell wall, including mycolic acid-arabinogalactan (mAG) and liparabinomannan (LAM), leading to anti-mycobacterial activity against Mycobacterium tuberculosis. UGM-IN-1 is useful for research on tuberculosis, including drug-resistant tuberculosis .
    UGM-IN-1
  • HY-180408
    Platyphylloside 90803-80-8
    Platyphylloside is an anti-virus agent that can be isolated from the bark of Alnus japonica. Platyphylloside exhibits activity against H9N2 avian influenza virus. Platyphylloside can be used for the research of influenza.
    Platyphylloside
  • HY-180451
    Antibacterial agent 310 10300-57-9
    Antibacterial agent 310 (compound 2) is a bis-benzimidazole-derived chelating ligand exhibiting antibacterial activity. Antibacterial agent 310 shows inhibition activity against intracellular viruses. Antibacterial agent can be used for antibacterial research.
    Antibacterial agent 310
  • HY-180452
    HAT-IN-10 2998560-77-1
    HAT-IN-10 (Compound 12a) is an anti-human African trypanosomiasis (HAT) agent, with an EC50 value of 0.23 μM for T. brucei. HAT-IN-10 can be used for research on HAT.
    HAT-IN-10
  • HY-180456
    Phosphatase-IN-2 2361524-76-5 98%
    Phosphatase-IN-2 (Compound 26) is a CpxA phosphatase inhibitor. Phosphatase-IN-2 can be used in the research of Escherichia coli infection.
    Phosphatase-IN-2
  • HY-180458
    SARS-CoV-2 Mpro-IN-52 3035282-25-5
    SARS-CoV-2 Mpro-IN-52 (compound 47) is a potent SARS-CoV-2 main protease (MPro) inhibitor (EC50 = 0.0099 µM) with antiviral activity. SARS-CoV-2 Mpro-IN-52 exhibits potent and broad-spectrum activity against MERS, OC43, 229E with EC50s of 0.00961, 0.138, and 0.117 µM. SARS-CoV-2 Mpro-IN-52 can be used for COVID-19 research.
    SARS-CoV-2 Mpro-IN-52
  • HY-180459
    FabH-IN-3 1224164-25-3 98%
    FabH-IN-3 (Compound 12) is an inhibitor of FabH. FabH-IN-3 exhibits MIC against Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Staphylococcus aureus are all 50 μg/mL. FabH-IN-3 can be used for research on Gram-negative bacterial infections.
    FabH-IN-3
  • HY-180483
    Antifungal agent 144 98%
    Antifungal agent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with an MIC of 7.5 μg/mL. Antifungal agent 144 simultaneously inhibits chitin deacetylase AngCDA and 1,3-β-glucan synthase. Antifungal agent 144 functions by disrupting the integrity of the fungal cell wall and does not bind to Ergosterol (HY-N0181). Antifungal agent 144 can be used for research on Aspergillus niger infections.
    Antifungal agent 144
  • HY-180501
    Alloc-NH-PEG8-PA 2897625-33-9
    Alloc-NH-PEG8-PA (Compound 48) is a linker that can be used for coupling Pimodivir (HY-12353A).
    Alloc-NH-PEG8-PA
  • HY-180502
    N-Succinyl-D-alanine 112243-89-7 98%
    N-Succinyl-D-alanine, a natural cell wall precursor analogue, is a peptide ligand of antibiotic Ristocetin A.
    N-Succinyl-D-alanine
  • HY-180510
    BFC220 143-85-1
    BFC220 is a covalent SARS-CoV-2 Mpro inhibitor with an IC50 of 2.77 μM. BFC220 can be used for antiviral research.
    BFC220
  • HY-180511
    MurA-IN-7 586395-04-2
    MurA-IN-7 (Compound 9) is a reversible MurA covalent inhibitor with an IC50 value of 164 μM. MurA-IN-7 can be used in antibacterial research.
    MurA-IN-7
  • HY-180516
    BFC204 154419-89-3
    BFC204 is a SARS-CoV-2 Mpro inhibitor with a kinact/Ki value of 619 mol/s.
    BFC204
  • HY-180521
    Piroctone 50650-76-5
    Piroctone is a potent hydroxypyridone antimicrobial agent that shows remarkable activity against fungi including Candida species. Piroctone inhibits hyphal induction of Candida albicans. Piroctone can efficiently chelate intracellular iron to induce relevant cytotoxicity in neuroblastoma cells. Piroctone can be used for antimicrobial and neuroblastoma research.
    Piroctone
  • HY-180525
    PB2-IN-2 98%
    PB2-IN-2 is an orally active PB2 inhibitor with RNA-dependent RNA Polymerase (RNP) IC50 = 0.2 nM, LRA (Ligand Receptor Assay) EC50 = 0.8 nM, Cytopathic Effect (CPE) EC50 = 0.1 nM. PB2-IN-2 exhibits broad-spectrum, nanomolar antiviral potency against a panel of influenza A strains (including H1N1pdm09, Lyon/1337/2007/H1N1, Tex12-Like/H3N2, PR/8/34/H1N1, WSN/1933/H1N1, rPR8(H1N1)/H7N9 with EC50 = 1.5, 3.6, 3.7, 13.8, 2.9 and 9.8 nM and all the CC50 values > 2 μM. PB2-IN-2 possesses an excellent pharmacokinetic profile and metabolic stability. PB2-IN-2 can be used for anti-influenza research.
    PB2-IN-2
  • HY-180544
    TrmD-IN-1
    TrmD-IN-1 (compound 8h) is a selective Staphylococcus aureus tRNA m1 G37 methyltransferase (TrmD) inhibitor with a KD of 2.48 μM and an IC50 of 1.16 μM. TrmD-IN-1 exhibits selectivity over E. coli (KD > 30 μM) and H. influenzae TrmD (KD > 30 μM) and Trm5 (IC50 > 30 μM).
    TrmD-IN-1
  • HY-18062R
    Pyrimethamine (Standard) 58-14-0 98%
    Pyrimethamine (Standard) is the analytical standard of Pyrimethamine. This product is intended for research and analytical applications. Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate.
    Pyrimethamine (Standard)
  • HY-180672
    Antifungal agent 145 98%
    Antifungal agent 145 (Compound 14') is a highly effective fungicide. Antifungal agent 145 exhibits MICs against Candida albicans, Candida tropicalis, and Cryptococcus neoformans of 4, 8, and 8 μg/mL respectively. Antifungal agent 145 exerts a potent and rapid bactericidal effect by disrupting the fungal cell membrane, and can effectively inhibit and destroy biofilms. Antifungal agent 145 has improved safety and can be used in antifungal research.
    Antifungal agent 145
  • HY-180673
    Mpro/RdRp-IN-1
    Mpro/RdRp-IN-1 (Compound 1) is a dual-target inhibitor against SARS-CoV-2, targeting RdRp (EC50 = 25.45) and Mpro (IC50 = 125.4 μM). Mpro/RdRp-IN-1 exhibits EC₅₀ for HCoV-OC43 of 4.79 μM, and the selectivity index (SI) is 10.89. Mpro/RdRp-IN-1 can be used for studying SARS-CoV-2 and HCoV-OC43 infections.
    Mpro/RdRp-IN-1
Cat. No. Product Name / Synonyms Application Reactivity