2. Epigenetics
  3. RNA MTase
  4. TrmD-IN-1

TrmD-IN-1 (compound 8h) is a selective Staphylococcus aureus tRNA m1 G37 methyltransferase (TrmD) inhibitor with a KD of 2.48 μM and an IC50 of 1.16 μM. TrmD-IN-1 exhibits selectivity over E. coli (KD > 30 μM) and H. influenzae TrmD (KD > 30 μM) and Trm5 (IC50 > 30 μM).

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TrmD-IN-1

TrmD-IN-1 Chemical Structure

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TrmD-IN-1 Related Antibodies

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Description

TrmD-IN-1 (compound 8h) is a selective Staphylococcus aureus tRNA m1 G37 methyltransferase (TrmD) inhibitor with a KD of 2.48 μM and an IC50 of 1.16 μM. TrmD-IN-1 exhibits selectivity over E. coli (KD > 30 μM) and H. influenzae TrmD (KD > 30 μM) and Trm5 (IC50 > 30 μM)[1].

IC50 & Target[1]

S. aureus TrmD

1.16 μM (IC50)

S. aureus TrmD

2.48 μM (Kd)

E. coli TrmD

>30 μM (Kd)

H. influenzae TrmD

>30 μM (Kd)

Trm5

>30 μM (IC50)

Molecular Weight

287.28

Formula

C11H13N9O
SMILES

O=C1NC=NC2=C1C(C3=CN(N=N3)CCNC(N)=N)=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TrmD-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrmD-IN-1RNA MTaseRNA MethyltransferaseMETTLStaphylococcus aureustRNA m1 G37 methyltransferaseTrm5E. coliH. influenzaeInhibitorinhibitorinhibit

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