TrmD-IN-1
TrmD-IN-1 (compound 8h) is a selective Staphylococcus aureus tRNA m1 G37 methyltransferase (TrmD) inhibitor with a KD of 2.48 μM and an IC50 of 1.16 μM. TrmD-IN-1 exhibits selectivity over E. coli (KD > 30 μM) and H. influenzae TrmD (KD > 30 μM) and Trm5 (IC50 > 30 μM).
For research use only. We do not sell to patients.
- Formula: C11H13N9O
- Molecular Weight:287.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
S. aureus TrmD 1.16 μM (IC50) |
S. aureus TrmD 2.48 μM (Kd) |
E. coli TrmD >30 μM (Kd) |
H. influenzae TrmD >30 μM (Kd) |
Trm5 >30 μM (IC50) |
Chemical Information
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Molecular Weight 287.28
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Formula C11H13N9O
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SMILES
O=C1NC=NC2=C1C(C3=CN(N=N3)CCNC(N)=N)=CN2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TrmD-IN-1 Related Classifications
HY-180544 Related Classifications
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