2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2259R
    Curcumenol (Standard) 19431-84-6 98%
    Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells.
    Curcumenol (Standard)
  • HY-N2344R
    Procyanidin A1 (Standard) 103883-03-0
    Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.
    Procyanidin A1 (Standard)
  • HY-N2360R
    Hinokiflavone (Standard) 19202-36-9 98%
    Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity.
    Hinokiflavone (Standard)
  • HY-N2376R
    Chrysin-7-O-glucuronide (Standard) 35775-49-6
    Chrysin-7-O-glucuronide (Standard) is the analytical standard of Chrysin-7-O-glucuronide (Hy-N2376). This product is intended for research and analytical applications. Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury.
    Chrysin-7-O-glucuronide (Standard)
  • HY-N2393A
    Kukoamine B mesylate 1375179-86-4 98%
    Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with Kd values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .
    Kukoamine B mesylate
  • HY-N2410R
    N-trans-Feruloyltyramine (Standard) 66648-43-9
    N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research.
    N-trans-Feruloyltyramine (Standard)
  • HY-N2414R
    Periplogenin (Standard) 514-39-6 98%
    Periplogenin (Standard) is the analytical standard of Periplogenin (HY-N2414). Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis.
    Periplogenin (Standard)
  • HY-N2420R
    Flavokawain A (Standard) 3420-72-2
    Flavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer.
    Flavokawain A (Standard)
  • HY-N2437R
    Methylophiopogonanone A (Standard) 74805-92-8
    Methylophiopogonanone A (Standard) is the analytical standard of Methylophiopogonanone A. This product is intended for research and analytical applications. Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties.
    Methylophiopogonanone A (Standard)
  • HY-N2441R
    Methylophiopogonone A (Standard) 74805-90-6
    Methylophiopogonone A (Standard) is the analytical standard of Methylophiopogonone A. This product is intended for research and analytical applications. Methylophiopogonone A, a homoisoflavonoid isolated from the tuberous roots of Ophiopogon japonicas, shows anti-inflammatory activity.
    Methylophiopogonone A (Standard)
  • HY-N2465R
    Methylsticin (Standard) 495-85-2 98%
    Methylsticin (Standard) is the analytical standard of Methylsticin. This product is intended for research and analytical applications. Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity.
    Methylsticin (Standard)
  • HY-N2468R
    Xylobiose (Standard) 6860-47-5 98%
    Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome.
    Xylobiose (Standard)
  • HY-N2473R
    Methylnissolin-3-O-glucoside (Standard) 94367-42-7
    Methylnissolin-3-O-glucoside (Standard) is the analytical standard of Methylnissolin-3-O-glucoside. This product is intended for research and analytical applications. Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects.
    Methylnissolin-3-O-glucoside (Standard)
  • HY-N2478R
    Taraxasteryl acetate (Standard) 6426-43-3
    Taraxasteryl acetate (Standard) is the analytical standard of Taraxasteryl acetate. This product is intended for research and analytical applications. Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasterol acetate promotes RNF31 degradation by activating autophagy. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment.
    Taraxasteryl acetate (Standard)
  • HY-N2481R
    Oroxylin A-7-O-glucuronide (Standard) 36948-76-2
    Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities.
    Oroxylin A-7-O-glucuronide (Standard)
  • HY-N2485R
    4'-Methoxyresveratrol (Standard) 33626-08-3
    4'-Methoxyresveratrol (Standard) is the analytical standard of 4'-Methoxyresveratrol. This product is intended for research and analytical applications. 4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
    4'-Methoxyresveratrol (Standard)
  • HY-N2518R
    Agnuside (Standard) 11027-63-7 98%
    Agnuside (Standard) is the analytical standard of Agnuside. This product is intended for research and analytical applications. Agnuside is used in the study of asthma, inflammation, and angiogenic diseases. Agnuside is an orally active compound that can be extracted from Vitex negundo.
    Agnuside (Standard)
  • HY-N2524R
    Camelliaside A (Standard) 135095-52-2
    Camelliaside A (Standard) is the analytical standard of Camelliaside A. This product is intended for research and analytical applications. Camelliaside A is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace.
    Camelliaside A (Standard)
  • HY-N2535R
    Coniferaldehyde (Standard) 458-36-6 98%
    Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities.
    Coniferaldehyde (Standard)
  • HY-N2572R
    Eupafolin (Standard) 520-11-6
    Eupafolin (Standard) is the analytical standard of Eupafolin. This product is intended for research and analytical applications. Eupafolin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells.
    Eupafolin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity