2. Neurological Disease

Neurological Disease (神経疾患)

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

製品番号 製品名 CAS 番号 純度 構造式
  • HY-P4782
    Acetyl-ACTH (3-24) (human, bovine, rat) 1815617-99-2 98%
    Acetyl-ACTH (3-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. POMC peptides such as adrenocorticotrophin (ACTH), which is the precursor of α-MSH, is also an agonist at the MC-1 receptor.
    Acetyl-ACTH (3-24) (human, bovine, rat)
  • HY-P4784
    Acetyl-ACTH (4-24) (human, bovine, rat) 1815618-00-8 98%
    Acetyl-ACTH (4-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. POMC peptides such as adrenocorticotrophin (ACTH), which is the precursor of α-MSH, is also an agonist at the MC-1 receptor.
    Acetyl-ACTH (4-24) (human, bovine, rat)
  • HY-P4786
    Acetyl-ACTH (7-24) (human, bovine, rat) 1815618-01-9 98%
    Acetyl-ACTH (7-24) (human, bovine, rat) causes a marked decrease of ACTH-evoked corticosterone and aldosterone release.
    Acetyl-ACTH (7-24) (human, bovine, rat)
  • HY-P4788
    Acetyl-Amyloid β-Protein (1-6) amide 903883-22-7 98%
    Acetyl-Amyloid β-Protein (1-6) amide is a hexapeptide that contains a potential copper(II) binding site. Acetyl-Amyloid β-Protein (1-6) amide can be used for research of Alzheimer's disease and related disorders.
    Acetyl-Amyloid β-Protein (1-6) amide
  • HY-P4806
    Perisulfakinin 125131-58-0 98%
    Perisulfakinin, a satiety signaling neuropeptide, inhibits the activity of central neurons promoting general activity.
    Perisulfakinin
  • HY-P4807
    Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) 122071-54-9 98%
    Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) (PBAN), a member of the PBAN/Pyrokinin neuropeptide family, characterized by a common amino acid sequence FXPRLamide motif in the C-terminus.
    Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea)
  • HY-P4815
    Prokineticin 2 Isoform 2 (human) 423206-00-2 98%
    Prokineticin 2 Isoform 2 (human) is a hypothalamic neuropeptide. Prokineticin 2 Isoform 2 (human) decreases food intake and involves in thermoregulation and energy metabolism in rodents. Prokineticin 2 has the potential for the research of hyperglycemia, metabolic syndrome (MetS) and obesity.
    Prokineticin 2 Isoform 2 (human)
  • HY-P4832
    Acetyl-Tau Peptide (273-284) amide 1684399-52-7 98%
    Acetyl-Tau Peptide (273-284) amide is an acetylated Tau peptide fragment. Acetyl-Tau Peptide (273-284) amide limits the substantial aggregation of Ac-Aβ(25–35)-NH2 and can be used as an inhibitor of Ac-Aβ(25–35)-NH2. Acetyl-Tau Peptide (273-284) amide can be used as an experimental model to investigate the Aβ/Tau cross-interaction .
    Acetyl-Tau Peptide (273-284) amide
  • HY-P4872
    Alarin (human) 909409-86-5 98%
    Alarin (human) is a hypothalamic neuropeptide belonging to the galanin family of peptides. Alarin (human) has the signal sequence of the GALP precursor peptide and the first 5 aa of the mature GALP.
    Alarin (human)
  • HY-P4873
    Amylin (20-29) (human) 118068-30-7 98%
    Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors.
    Amylin (20-29) (human)
  • HY-P4878
    5-TAMRA-Amyloid β-Protein (1-40) 1802087-81-5 98%
    5-TAMRA-Amyloid β-Protein (1-40) is a fluorescent (TAMRA)-labeled Amyloid β-Protein (1-40), Abs/Em=544/572 nm.
    5-TAMRA-Amyloid β-Protein (1-40)
  • HY-P4882
    (Pyr3)-Amyloid β-Protein (3-42) 183449-57-2 98%
    (Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits.
    (Pyr3)-Amyloid β-Protein (3-42)
  • HY-P4888
    (Pyr11)-Amyloid β-Protein (11-40) 192377-94-9 98%
    (Pyr11)-Amyloid β-Protein (11-40) (A beta 11pE-40) is a peptide. (Pyr11)-Amyloid β-Protein (11-40) can be used for the research of Alzheimer's disease.
    (Pyr11)-Amyloid β-Protein (11-40)
  • HY-P4889
    (Gly22)-amyloid beta-protein(1-40) 175010-18-1 98%
    (Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) is a peptide. (Gly22)-amyloid beta-protein(1-40) can be used for the research of Alzheimer's disease.
    (Gly22)-amyloid beta-protein(1-40)
  • HY-P4899
    β-Secretase substrate VI, fluorogenic 310427-94-2 98%
    β-Secretase substrate VI, fluorogenic is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). β-Secretase substrate VI, fluorogenic can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction.
    β-Secretase substrate VI, fluorogenic
  • HY-P4904
    RFRP-3 (rat) 420088-80-8 98%
    RFRP-3 (rat) is a neuropeptide. RFRP-3 (rat) inhibits gonadotropin secretion, causing a marked increase in ghrelin mRNA and plasma growth hormone levels.
    RFRP-3 (rat)
  • HY-P4923
    Tau Peptide (1-16) (human) 2022956-53-0 98%
    Tau Peptide (1-16) (human) is aTau fragment.
    Tau Peptide (1-16) (human)
  • HY-P4924
    Tau Peptide (244-274) (Repeat 1 Domain) 330456-24-1 98%
    Tau Peptide (244-274) (Repeat 1 Domain) is aTau fragment.
    Tau Peptide (244-274) (Repeat 1 Domain)
  • HY-P4926
    Mca-SEVKMDAEFRK(Dnp)RR-NH2 1802078-33-6 98%
    Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research.
    Mca-SEVKMDAEFRK(Dnp)RR-NH2
  • HY-P4927
    Tau Peptide (245-274) (Repeat 1 Domain) 1428134-39-7 98%
    Tau Peptide (245-274) (Repeat 1 Domain) is aTau fragment.
    Tau Peptide (245-274) (Repeat 1 Domain)
製品番号 製品名 / Synonyms Application Reactivity