2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. 상품명 CAS No. Purity 화학구조
  • HY-W700240
    Triazolomethylindole-3-acetic acid 177270-91-6 98%
    Triazolomethylindole-3-acetic acid is a metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist Rizatriptan HY-B0206).
    Triazolomethylindole-3-acetic acid
  • HY-W700241
    Norharman-d7 1216503-21-7 98%
    Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
    Norharman-d7
  • HY-W700319
    (Rac)-5-Carboxy tolterodine 1076199-77-3 98%
    (Rac)-5-Carboxy tolterodine is an inactive metabolite of the muscarinic acetylcholine receptor antagonist Tolterodine (HY-A0024).
    (Rac)-5-Carboxy tolterodine
  • HY-W700741
    2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride 13473-53-5 98%
    2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride is a metabolite of the anorectic agent Mazindol.
    2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride
  • HY-W701635
    Meclizine N-oxide 114624-69-0 98%
    Meclizine N-oxide is a metabolite of the histamine H1 receptor antagonist Meclizine (HY-B0349A).
    Meclizine N-oxide
  • HY-W701936
    2-O-Desmethyl cisapride 102671-04-5 98%
    2-O-Desmethyl cisapride is a minor Cisapride metabolite.
    2-O-Desmethyl cisapride
  • HY-W701990
    2-(Propylamino)propiophenone hydrochloride） 879667-46-6 98%
    2-(Propylamino)propiophenone hydrochloride is s a drug derivative.
    2-(Propylamino)propiophenone hydrochloride）
  • HY-W702646
    Hydroxymethyl tolperisone hydrochloride 352233-14-8 98%
    Hydroxymethyl tolperisone hydrochloride is a metabolite of Tolperisone (HY-B1139A). Hydroxymethyl tolperisone hydrochloride is formed from tolperisone primarily by the cytochrome P450 (CYP) isoform CYP2D6 and to a lesser extent by CYP2C19 and CYP1A2.
    Hydroxymethyl tolperisone hydrochloride
  • HY-W703540
    Deracoxib-d4 1794780-24-7 98%
    Deracoxib-d4 (SC 046-d4; SC 59046--d4) is deuterium labeled Deracoxib (HY-17509). Deracoxib, an orally active COX-2 inhibitor, is a veterinary nonsteroidal anti-inflammatory agent used exclusively in dogs. Deracoxib inhibits the COX-2 enzyme to reduce the production of prostaglandins, effectively controlling pain and inflammation after canine soft tissue surgery. Deracoxib reduces the inhibition of COX-1 and lowers the risk of gastrointestinal side effects. Deracoxib induces tumor cell cycle arrest and apoptosis, and shows anti-tumor activity in canine osteosarcoma, breast tumors and bladder transitional cell carcinomas.
    Deracoxib-d4
  • HY-W703869
    5-Hydroxy NMT oxalate 1975-81-1 98%
    5-Hydroxy NMT (N-Methylserotonin) oxalate is a metabolite of 5-HT and belongs to the tryptamine class of compounds. Elevated levels of 5-Hydroxy NMT oxalate in plasma are associated with cocaine addiction.
    5-Hydroxy NMT oxalate
  • HY-W704749
    7-Hydroxychlorpromazine hydrochloride 51938-11-5 98%
    7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis.
    7-Hydroxychlorpromazine hydrochloride
  • HY-W704916
    3-Methylbuphedrone hydrochloride 1797911-07-9 98%
    3-Methylbuphedrone hydrochloride is a methylated analog of Buphedrone.
    3-Methylbuphedrone hydrochloride
  • HY-W706595
    N,α-Diethylphenethylamine hydrochloride 29805-52-5 99.9%
    N,α-Diethylphenethylamine hydrochloride is an N-substituted amphetamine with an ethyl group attached to the amine. N,α-Diethylphenethylamine hydrochloride is an anorectic.
    N,α-Diethylphenethylamine hydrochloride
  • HY-W707126
    4-Methoxy PV8 hydrochloride 2749302-60-9 98%
    4-Methoxy PV8 hydrochloride is a para-methoxy analog of PV8.
    4-Methoxy PV8 hydrochloride
  • HY-W708023
    5-APDI hydrochloride 152623-95-5 98%
    5-APDI hydrochloride is an indane with an amphetamine-like aminopropane group. 5-APDI hydrochloride inhibits the uptake of serotonin, dopamine, and norepinephrine by crude synaptosomes (IC50 values of 82 nM, 1,847 nM, and 849 nM, respectively).
    5-APDI hydrochloride
  • HY-W708033
    25E-NBOMe hydrochloride 1539266-39-1 99.9%
    25E-NBOMe hydrochloride is a derivative of 2C-E having an N-(2-methoxybenzyl) addition at the amine. 25E-NBOMe hydrochloride is a selective /b>5-HT2A receptor agonist.
    25E-NBOMe hydrochloride
  • HY-W708197
    Tolterodine dimer 854306-72-2 98%
    Tolterodine dimer is the impurity of Tolterodine (HY-A0024). Tolterodine is a potent muscarinic receptor antagonist.
    Tolterodine dimer
  • HY-W708286
    α-Pyrrolidinobutiothiophenone hydrochloride 2518265-88-6 98%
    α-Pyrrolidinobutiothiophenone hydrochloride is a synthetic drug derivative.
    α-Pyrrolidinobutiothiophenone hydrochloride
  • HY-W709830
    α-Propylaminopentiophenone hydrochloride 18268-15-0 98%
    α-Propylaminopentiophenone hydrochloride is a drug derivative.
    α-Propylaminopentiophenone hydrochloride
  • HY-W713312
    2,6-DMA hydrochloride 3904-11-8 98%
    2,6-DMA hydrochloride is classified as an amphetamine. 2,6-DMA hydrochloride is a serotonin 5-HT2 receptor agonist with an apparent pA2 value of 5.09.
    2,6-DMA hydrochloride
Cat. No. 상품명 / Synonyms Application Reactivity