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Risedronate sodium (Synonyms: Risedronic Acid Sodium)

Cat. No.: HY-B0119 Purity: ≥98.0%
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Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.

For research use only. We do not sell to patients.

Risedronate sodium Chemical Structure

Risedronate sodium Chemical Structure

CAS No. : 115436-72-1

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Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption. Target: Risedronate sodium, which was promoted in Croatia a few months ago, is the latest (III) generation of bisphosphonates, the most efficient anti-resorption drugs that inhibit osteoclast-mediated bone resorption and change the bone metabolism. Risedronate sodium is hence the first line of bisphosphonates for the reduction of vertebral and non-vertebral fracture risks in postmenopausal women with osteoporosis or those with a high risk of osteoporosis. It also efficiently prevents bone loss or improves bone density in men and women on a long-term corticosteroid therapy [1]. The administration of 20 and 25 mg/kg risedronate sodium for 4 days led to decreases of parasitemia of 68.9% and 83.6%, respectively. On the seventh day of treatment the inhibitions were 63% and 88.9% with 20 and 25 mg/kg, respectively. After recovering the parasitemia, a dose-response curve was obtained for estimating the ID50 (dose causing 50% inhibition), equivalent to 17 ± 1.8 mg/kg after 7 days of treatment. Four days after the interruption of treatment (11 days postinfection), the parasitemias of the groups treated with 10, 15, 20, and 25 mg/kg/day were 15.3%, 15.9%, 15.2%, and 5.7%, respectively. Conversely, the group that received PBS presented parasitemia of 25.6%. Among the groups treated with risedronate sodium, only the animals that received 25 mg/kg had a significant inhibition of 77.8% (see Table S1 in the supplemental material), demonstrating that even after treatment discontinuation, the parasitemia of the animals remained low in relation to that of the controls [2]. Clinical indications: Bone resorption; Male osteoporosis; Osteogenesis imperfecta; Osteoporosis; Pagets bone disease Toxicity: abdominal pain; anxiety, back pain; belching, bladder irritation; bone disorders and pain; bronchitis; bursitis; cataracts; chest pain; colitis; constipation; depression; diarrhea; difficulty breathing

Molecular Weight







Room temperature in continental US; may vary elsewhere.


4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (27.30 mM; Need ultrasonic)

DMSO : 1 mg/mL (3.28 mM; ultrasonic and warming and heat to 80°C)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2777 mL 16.3886 mL 32.7772 mL
5 mM 0.6555 mL 3.2777 mL 6.5554 mL
10 mM 0.3278 mL 1.6389 mL 3.2777 mL
*Please refer to the solubility information to select the appropriate solvent.
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